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Characterization and abolishment of the cyclopiazonic acids produced by Aspergillus oryzae HMP-F28
Cao, Ting1,2; Ling, Junhong3; Liu, Yi1,3; Chen, Xiaoqi1,2; Tian, Xiaoyue1,3; Meng, Dali3; Pan, Huaqi1; Hu, Jiangchun1; Wang, Nan1
Corresponding AuthorWang, Nan(wangn@iae.ac.cn)
2018
Source PublicationBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN0916-8451
Volume82Issue:10Pages:1832-1839
AbstractExtracellular alkalinization and H2O2 production are important early events during induced resistance establishment in plants. In a screen for metabolites as plant resistance activators from 98 fungal isolates associated with marine sponge Hymeniacidon perleve, the cyclopiazonic acids (CPAs) produced by Aspergillus oryzae HMP-F28 induced significant extracellular alkalinization coupled with augmented H2O2 production in tobacco cell suspensions. Bioassay-guided fractionation led to the isolation and structural elucidation of a new CPA congener (4, 3-hydroxysperadine A) and three known ones (1-3). To construct a mutasynthetic strain to generate unnatural CPA analogues, a hybrid pks-nrps gene (cpaS) was disrupted to abolish the production of the critical precursor of cyclo-acetoacetyl-L-tryptophan (cAATrp) and all the downstream CPA products. Elimination of cAATrp will allow cAATrp mimics being processed by the CPA biosynthetic machinery to produce CPA derivatives with designed structural features.
KeywordCyclopiazonic acid Aspergillus oryzae oxidative burst hybrid pks-nrps plant immune
DOI10.1080/09168451.2018.1490170
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
WOS SubjectBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000445240200020
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/129434
Collection中国科学院金属研究所
Corresponding AuthorWang, Nan
Affiliation1.Chinese Acad Sci, Inst Appl Ecol, Shenyang, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Cao, Ting,Ling, Junhong,Liu, Yi,et al. Characterization and abolishment of the cyclopiazonic acids produced by Aspergillus oryzae HMP-F28[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2018,82(10):1832-1839.
APA Cao, Ting.,Ling, Junhong.,Liu, Yi.,Chen, Xiaoqi.,Tian, Xiaoyue.,...&Wang, Nan.(2018).Characterization and abolishment of the cyclopiazonic acids produced by Aspergillus oryzae HMP-F28.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,82(10),1832-1839.
MLA Cao, Ting,et al."Characterization and abolishment of the cyclopiazonic acids produced by Aspergillus oryzae HMP-F28".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 82.10(2018):1832-1839.
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