Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property

doi:10.1016/j.jmst.2018.09.026

IMR OpenIR

	Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property
	Guo, F.1,2; Jiao, K.1,2; Bai, Y.1,2; Guo, J.3; Chen, Q.4; Yang, R.1,2; Zhang, X.1,2
通讯作者	Guo, J.(guojing@dlpu.edu.cn) ; Zhang, X.(xingzhang@imr.ac.cn)
	2019
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	35 期号:1 页码:207-215
摘要	Transcatheter aortic heart valves (TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate (PEGDA) hydrogels and anisotropic high-shrinkage polyethylene terephthalate/polyamide6 (PET-PA6) fabric (PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets. Dynamic mechanical analyses (DMA) indicated that PEGDA/PET-PA6 composites possessed anisotropic mechanical properties (i.e., storage moduli similar to 23.30 +/- 1.36 MPa parallel to the aligned fabric fibers and similar to 9.68 +/- 0.90 MPa perpendicular to the aligned fibers at 1 Hz) that were comparable to aortic valve leaflets. The PEGDA/PET-PA6 composites with smooth surfaces were highly hydrophilic (contact angle similar to 41.6 degrees +/- 3.8 degrees) and had low-fouling properties without platelet adhesion, suggesting a low risk of thrombogenicity when they interacted with blood. Furthermore, transcatheter aortic heart valves were fabricated using nitinol self-expanding frames and PEGDA/PET-PA6 composites as artificial leaflets, which presented excellent hemodynamic performance with a large orifice area (1.75 cm(2)) and low regurgitation (3.41%), thus meeting the requirements of ISO 5840-3 standard. Therefore, PEGDA/PET-PA6 composites had suitable mechanical properties, good biocompatibility, and low-fouling properties, indicating that they might be used for TAHVs in the future. (C) 2018 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Transcatheter aortic heart valve Textile fabric Poly(ethylene glycol) diacrylate Anti-fouling
资助者	National Natural Science Foundation of China ; Hundred-Talent Program from Chinese Academy of Sciences
DOI	10.1016/j.jmst.2018.09.026
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31670981] ; National Natural Science Foundation of China[31300788] ; Hundred-Talent Program from Chinese Academy of Sciences
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000449263900028
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/130210
专题	中国科学院金属研究所
通讯作者	Guo, J.; Zhang, X.
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 239056, Anhui, Peoples R China 3.Dalian Polytech Univ, Sch Text & Mat Engn, Dalian 116034, Peoples R China 4.Lumenous Peiertech, Jiangyin 214437, Peoples R China
推荐引用方式 GB/T 7714	Guo, F.,Jiao, K.,Bai, Y.,et al. Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(1):207-215.
APA	Guo, F..,Jiao, K..,Bai, Y..,Guo, J..,Chen, Q..,...&Zhang, X..(2019).Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(1),207-215.
MLA	Guo, F.,et al."Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.1(2019):207-215.