| Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis | |
| Li, Yugang1; Wang, Lei1; Chen, Shanshan2; Yu, Dan1; Sun, Weifeng1; Xin, Shijie1 | |
| Corresponding Author | Xin, Shijie(sjxin@cmu.edu.cn) |
| 2019-05-01 | |
| Source Publication | YONSEI MEDICAL JOURNAL
 |
| ISSN | 0513-5796 |
| Volume | 60Issue:5Pages:429-439 |
| Abstract | Purpose: To explore the effects of biodegradable magnesium alloy stents (BMAS) on remodeling of vein graft (VG) anastomotic restenosis. Materials and Methods: To establish a VG restenosis model, seventy two New Zealand rabbits were randomly divided into three groups according to whether a stent was implanted in the graft vein or not. BMASs and 316L stainless steel stents were implanted in BMAS and 316L groups, respectively, while no stent was implanted in the no-treatment control group (NC group). Loss of lumen diameter in the graft vein was measured in all three groups. Upon harvesting VG segments to evaluate intimal proliferation and re-endothelization, the degradation and biological safety of the stents were observed to explore the effects of BMAS on VG remodeling. Results: Model establishment and stent implantation were successful. The BMAS reduced lumen loss, compared with the control group (0.05 +/- 0.34 mm vs. 0.90 +/- 0.39 mm, p=0.001), in the early stage. The neointimal area was smaller in the BMAS group than the 316L group after 4 months (4.96 +/- 0.66 mm(2) vs. 6.80 +/- 0.69 mm(2), p=0.017). Re-endothelialization in the BMAS group was better than that in the 316L group (p=0.001). Within 4 months, the BMAS had degraded, and the magnesium was converted to phosphorus and calcium. The support force of the BMAS began to reduce at 2-3 months after implantation, without significant toxic effects. Conclusion: BMAS promotes positive remodeling of VG anastomosis and has advantages over the conventional 316L stents in the treatment of venous diseases. |
| Keyword | Restenosis vascular graft biodegradable stent magnesium |
| Funding Organization | National Natural Science Foundation of China |
| DOI | 10.3349/ymj.2019.60.5.429 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81000136] |
| WOS Research Area | General & Internal Medicine |
| WOS Subject | Medicine, General & Internal |
| WOS ID | WOS:000465448300005 |
| Publisher | YONSEI UNIV COLL MEDICINE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/133112 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Xin, Shijie |
| Affiliation | 1.China Med Univ, Affiliated Hosp 1, Dept Vasc & Thyroid Surg, Shenyang 110001, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Yugang,Wang, Lei,Chen, Shanshan,et al. Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis[J]. YONSEI MEDICAL JOURNAL,2019,60(5):429-439. |
| APA | Li, Yugang,Wang, Lei,Chen, Shanshan,Yu, Dan,Sun, Weifeng,&Xin, Shijie.(2019).Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis.YONSEI MEDICAL JOURNAL,60(5),429-439. |
| MLA | Li, Yugang,et al."Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis".YONSEI MEDICAL JOURNAL 60.5(2019):429-439. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment