Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment

doi:10.1016/j.msec.2019.03.021

IMR OpenIR

	Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment
	Zhao, Jinlong 1,2; Zhai, Zhaofeng 1,2; Sun, Da 3,4; Yang, Chunguang 1; Zhang, Xinrui 1,2; Huang, Nan 1; Jiang, Xin 1; Yang, Ke 1
通讯作者	Yang, Chunguang(cgyang@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2019-07-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	100 页码:396-410
摘要	Stainless steel (SS) has been widely applied as one of the most efficient implant metal materials, although corrosion and infection in body environment are still challenging. Herein, an antibacterial passivation method was employed to enhance the antibacterial performance and corrosion resistance of the medical 316L SS. The result proved that the antibacterial-passivated 316L SS exhibited stable antibacterial activity and effectively inhibited the formation of bacterial biofilm. Electrochemical measurements combined with X-ray photoelectron spectroscopy technique were used to study the corrosion resistance and semiconductor behavior of passivated 316L SS immersed in simulated physiological environment. The results indicated that the 316L SS after anti-bacterial passivation treatment for 1 h, soaking in the medium for 10 days, showed satisfactory corrosion resistance attributing to proper Cu deposition in the passive film. The anodic stripping voltammetry measurement further confirmed that the Cu-bearing passive film could continuously release Cu ions into medium. The zebrafish test demonstrated an excellent in vivo biocompatibility for the 316L SS with antibacterial passivation for 0.5 and 1 h, respectively. In addition, changes of surface roughness, contact angle and chemical composition after antibacterial passivation played an important role in explaining the antibacterial mechanism, which could be clearly divided into contact killing and ionic release killing. Hence, the antibacterial passivation treatment was preliminarily proved as a potential way for enhancing the persistent antibacterial activity and corrosion resistance of 316L SS.
关键词	Stainless steel Passive film Antibacterial passivation treatment Cu ion Antibacterial activity
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China ; Natural Science Foundation of Zhejiang Province ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme ; Shenzhen Science and Technology Research Funding
DOI	10.1016/j.msec.2019.03.021
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFB0300205] ; National Natural Science Foundation of China[51501188] ; National Natural Science Foundation of China[51771199] ; State Key Program of National Natural Science of China[51631009] ; Natural Science Foundation of Zhejiang Province[LQ19E010004] ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme[SGLH20150213143207910] ; Shenzhen Science and Technology Research Funding[JCYJ 20160608153641020]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000466059700039
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/133354
专题	中国科学院金属研究所
通讯作者	Yang, Chunguang; Yang, Ke
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Wenzhou Univ, Inst Life Sci, Wenzhou 325000, Peoples R China 4.Wenzhou Med Univ, Sch Nursing, Chinese Amer Res Inst Diabet Complicat, Sch Pharmaceut Sci, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jinlong,Zhai, Zhaofeng,Sun, Da,et al. Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,100:396-410.
APA	Zhao, Jinlong.,Zhai, Zhaofeng.,Sun, Da.,Yang, Chunguang.,Zhang, Xinrui.,...&Yang, Ke.(2019).Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,100,396-410.
MLA	Zhao, Jinlong,et al."Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 100(2019):396-410.