In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect

doi:10.1016/j.jmst.2019.04.031

IMR OpenIR

	In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect
	Chen, Junxiu 1,2; Dong, Jiahui 1,2; Fu, Huameng 1; Zhang, Haifeng 1; Tan, Lili 1; Zhao, Dewei 3; Yang, Ke 1
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2019-10-01
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	35 期号:10 页码:2254-2262
摘要	In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank's solution. In vitro cytotoxicity test showed that Mg(69)Zn(27)Ca(4 )metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original phi 6 mm to phi 3.35 +/- 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Mg69Zn27Ca4 metal glass Degradation Cytocompatibility Bone substitutes
资助者	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Shenyang Key Research & Development and Technology Transfer Program
DOI	10.1016/j.jmst.2019.04.031
收录类别	SCI
语种	英语
资助项目	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Shenyang Key Research & Development and Technology Transfer Program[Z18-0-027]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000484531600019
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/135151
专题	中国科学院金属研究所
通讯作者	Tan, Lili; Yang, Ke
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
推荐引用方式 GB/T 7714	Chen, Junxiu,Dong, Jiahui,Fu, Huameng,et al. In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(10):2254-2262.
APA	Chen, Junxiu.,Dong, Jiahui.,Fu, Huameng.,Zhang, Haifeng.,Tan, Lili.,...&Yang, Ke.(2019).In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(10),2254-2262.
MLA	Chen, Junxiu,et al."In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.10(2019):2254-2262.