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In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect
Chen, Junxiu1,2; Dong, Jiahui1,2; Fu, Huameng1; Zhang, Haifeng1; Tan, Lili1; Zhao, Dewei3; Yang, Ke1
Corresponding AuthorTan, Lili(lltan@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
2019-10-01
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume35Issue:10Pages:2254-2262
AbstractIn the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank's solution. In vitro cytotoxicity test showed that Mg(69)Zn(27)Ca(4 )metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original phi 6 mm to phi 3.35 +/- 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordMg69Zn27Ca4 metal glass Degradation Cytocompatibility Bone substitutes
Funding OrganizationKey Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Shenyang Key Research & Development and Technology Transfer Program
DOI10.1016/j.jmst.2019.04.031
Indexed BySCI
Language英语
Funding ProjectKey Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Shenyang Key Research & Development and Technology Transfer Program[Z18-0-027]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000484531600019
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/135151
Collection中国科学院金属研究所
Corresponding AuthorTan, Lili; Yang, Ke
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China
3.Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
Recommended Citation
GB/T 7714
Chen, Junxiu,Dong, Jiahui,Fu, Huameng,et al. In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(10):2254-2262.
APA Chen, Junxiu.,Dong, Jiahui.,Fu, Huameng.,Zhang, Haifeng.,Tan, Lili.,...&Yang, Ke.(2019).In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(10),2254-2262.
MLA Chen, Junxiu,et al."In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.10(2019):2254-2262.
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