| Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants | |
| Du, Zhe1,3; Yu, Xiaoming2; Nie, Binen3; Zhu, Zhonglin4; Ibrahim, Muhammad2,5; Yang, Ke2; Tan, Lili2; Wang, You3 | |
| Corresponding Author | Tan, Lili(lltan@imr.ac.cn) ; Wang, You(drwangyou@126.com) |
| 2019-10-01 | |
| Source Publication | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| ISSN | 1552-4973 |
| Volume | 107Issue:7Pages:2388-2396 |
| Abstract | We investigated the effects of magnesium (Mg) on osteogenesis and bone resorption at a porous structure interface. A three-dimensional (3D)-printed porous Ti6Al4V implant coated with Mg was introduced, and polyether-ether-ketone wear particles were added to generate an animal model of implant loosening. We also examined the effects of Mg leach liquor on osteoblast/osteoclast gene expression, alkaline phosphatase activity, collagen secretion, tartrate-resistant acid phosphatase activity, and bone resorption in vitro. Mg inhibited the early stage of osteoclast differentiation and inhibited bone resorption in vitro and in vivo. However, Mg did not enhance osteogenesis in vitro or in vivo in the porous structures or in peripheral areas around the implants. For implants with porous structures, the Mg coating did not improve the osteogenic ability by itself, but could restrain peri-implant osteolysis, which may make it favorable for use in patients with osteoporosis. Further studies are needed to examine the precise mechanism of Mg-induced anti-osteolysis and the long-term effects of Mg-coated implants in humans. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2388-2396, 2019. |
| Keyword | magnesium osteolysis polyether-ether-ketone particles rabbit model Ti6Al4V implant |
| Funding Organization | National Key R&D Program of China |
| DOI | 10.1002/jbm.b.34332 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key R&D Program of China[2016YFC1101802] ; National Key R&D Program of China[2016YFC1101804] ; National Key R&D Program of China[2016YFC1] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000483702000019 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/135385 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Tan, Lili; Wang, You |
| Affiliation | 1.Peking Univ, Peoples Hosp, Trauma Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Bone & Joint Surg, Shanghai, Peoples R China 4.Jiangsu OKANI Med Technol Co Ltd, Suzhou, Peoples R China 5.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Du, Zhe,Yu, Xiaoming,Nie, Binen,et al. Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2019,107(7):2388-2396. |
| APA | Du, Zhe.,Yu, Xiaoming.,Nie, Binen.,Zhu, Zhonglin.,Ibrahim, Muhammad.,...&Wang, You.(2019).Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,107(7),2388-2396. |
| MLA | Du, Zhe,et al."Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 107.7(2019):2388-2396. |
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