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Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment
Guo, Yu1,2; Ren, Ling3; Xie, Kai1,2; Wang, Lei1,2; Yu, Baohai3; Jiang, Wenbo2; Zhao, Yanhui3; Hao, Yongqiang1,2
Corresponding AuthorWang, Lei(hyq_9hospital@hotmail.com) ; Zhao, Yanhui(yhzhao@imr.ac.cn) ; Hao, Yongqiang(118062@sh9hospital.org)
2020-01-31
Source PublicationADVANCED MATERIALS INTERFACES
ISSN2196-7350
Pages13
AbstractTi6Al4V scaffolds have high strength and corrosion resistance. 3D printing technology can optimize the pore structure of Ti6Al4V scaffolds, promoting bone tissue growth into the scaffolds to form firm osseointegrations. However, Ti6Al4V lacks biological activity. This defect can be overcome through surface modifications. Arc ion plating is employed to prepare titanium copper/titanium copper nitride (TiCu/Ti-Cu-N) multilayer coating, which is applied to 3D-printed porous Ti6Al4V scaffolds by selective laser melting and bearing 300-400 mu m pores. In addition to the excellent biological activity of copper, TiN shows superior corrosion resistance. The scaffold properties, osteogenesis, and osteointegration are evaluated in vitro and in vivo. Results show that human bone mesenchymal stem cells (hBMSCs) proliferate and adhere more effectively on coated scaffolds than on uncoated scaffolds. Further, the coating has a significant role in recruiting hBMSCs, and upregulation of the SDF-1 alpha/CXCR4 axis, p38 expression, and extracellular signal-related kinase (Erk) and Akt signaling pathway. The in vitro results are further confirmed by an animal experiment in the New Zealand white rabbit femur tibia defect. Overall, the TiCu/Ti-Cu-N-coated 3D-printed Ti6Al4V scaffold shows excellent biocompatibility and bioactivity in promoting bone repair. The underlying mechanism may involve recruiting BMSCs and promoting their osteogenic differentiation.
KeywordBMSC recruitment nitride-titanium-copper orthopedic implant osteogenesis selective laser melting
Funding OrganizationNational Key R&D Program of China
DOI10.1002/admi.201901632
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2016YFC1100600] ; National Key R&D Program of China[2016YFC1100604]
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS IDWOS:000510253900001
PublisherWILEY
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/137204
Collection中国科学院金属研究所
Corresponding AuthorWang, Lei; Zhao, Yanhui; Hao, Yongqiang
Affiliation1.Shanghai Jiao Tong Univ, A Shanghai Key Lab Orthopaed Implants, Dept Orthopaed Surg, Shanghai Peoples Hosp 9,Sch Med, Shanghai 200011, Peoples R China
2.Shanghai Jiao Tong Univ, Clin & Translat Res Ctr 3D Printing Technol, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Special Mat & Device Res Dept, Shenyang 110000, Peoples R China
Recommended Citation
GB/T 7714
Guo, Yu,Ren, Ling,Xie, Kai,et al. Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment[J]. ADVANCED MATERIALS INTERFACES,2020:13.
APA Guo, Yu.,Ren, Ling.,Xie, Kai.,Wang, Lei.,Yu, Baohai.,...&Hao, Yongqiang.(2020).Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment.ADVANCED MATERIALS INTERFACES,13.
MLA Guo, Yu,et al."Functionalized TiCu/Ti-Cu-N-Coated 3D-Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment".ADVANCED MATERIALS INTERFACES (2020):13.
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