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Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior
Guo, Feng1,2; Liu, Chang3,4; Han, Rizheng1,2; Lu, Qiang5,6; Bai, Yun1,2; Yang, Rui1,2; Niu, Dun4; Zhang, Xing1,2
Corresponding AuthorNiu, Dun(niudun666@hotmail.com) ; Zhang, Xing(xingzhang@imr.ac.cn)
2020-04-01
Source PublicationSCIENCE CHINA-MATERIALS
ISSN2095-8226
Volume63Issue:4Pages:629-643
AbstractNative heart valve leaflets with layered fibrous structures show anisotropic characteristics, allowing them to withstand complex mechanical loading for long-term cardiac cycles. Herein, two types of silk fibroin (SF) fiber membranes with anisotropic (ASF) and isotropic (ISF) properties were prepared by electrospinning, and were further combined with poly(ethylene glycol) diacrylate (PEGDA) hydrogels to serve as polymeric heart valve (PHV) substitutes (PEGDA-ASF and PEGDA-ISF). The uniaxial tensile tests showed obvious ani-sotropy of PEGDA-ASF with elastic moduli of 10.95 +/- 1.09 and 3.55 +/- 0.32 MPa, respectively, along the directions parallel and perpendicular to the fiber alignment, while PEGDA-ISF possessed isotropic property with elastic moduli of 4.54 +/- 0.43 MPa. The PHVs from both PEGDA-ASF and PEGDA-ISF presented appropriate hydrodynamic properties from pulse duplicator tests according to the ISO 5840-3 standard. However, finite element analysis (FEA) revealed the anisotropic PEGDA-ASF valve showed a lower maximum principle stress value (2.20 MPa) in commissures during diastole compared with that from the isotropic PEGDA-ISF valve (2.37 MPa). In the fully open state, the bending area of the PEGDA-ASF valve appeared in the belly portion and near the attachment line like native valves, however, which was close to free edges for the PEGDA-ISF valve. The Gauss curvature analysis also indicated that the anisotropic PEGDA-ASF valve can produce appropriate surface morphology by dynamically adjusting the movement of bending area during the opening process. Hence, anisotropy of PHVs with bio-inspired layered fibrous structures played important roles in mechanical and hydrodynamic behavior mimicking native heart valves.
Keywordanisotropy silk fibroin poly(ethylene glycol) heart valves finite element analysis
Funding OrganizationNational Natural Science Foundation of China ; Hundred-Talent Program from Chinese Academy of Sciences
DOI10.1007/s40843-019-1217-4
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31300788] ; Hundred-Talent Program from Chinese Academy of Sciences
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000519466600016
PublisherSCIENCE PRESS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/137659
Collection中国科学院金属研究所
Corresponding AuthorNiu, Dun; Zhang, Xing
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
3.Hong Kong Polytech Univ, Inst Text & Clothing, Hong Kong, Peoples R China
4.Northeastern Univ, Dept Chem, Shenyang 110004, Peoples R China
5.Soochow Univ, Natl Engn Lab Modern Silk, Suzhou 215123, Peoples R China
6.Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China
Recommended Citation
GB/T 7714
Guo, Feng,Liu, Chang,Han, Rizheng,et al. Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior[J]. SCIENCE CHINA-MATERIALS,2020,63(4):629-643.
APA Guo, Feng.,Liu, Chang.,Han, Rizheng.,Lu, Qiang.,Bai, Yun.,...&Zhang, Xing.(2020).Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior.SCIENCE CHINA-MATERIALS,63(4),629-643.
MLA Guo, Feng,et al."Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior".SCIENCE CHINA-MATERIALS 63.4(2020):629-643.
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