Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating

doi:10.1021/acsbiomaterials.9b01396

IMR OpenIR

	Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating
	Ullah, Ihsan 1,2; Siddiqui, Muhammad Ali 1,2; Liu, Hui 1,2; Kolawole, Sharafadeen Kunle 1,2; Zhang, Ji 1; Zhang, Shuyuan 1; Ren, Ling 1; Yang, Ke 1
通讯作者	Ren, Ling(lren@imr.ac.cn)
	2020-03-01
发表期刊	ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN	2373-9878
卷号	6 期号:3 页码:1355-1366
摘要	Implant-related infections are a major concern in total joint prostheses, occurring up to 3% in operations. In this work, 5% Zn2+ was added in I-TA to offset bacterial activity and 5% Sr2+ was also incorporated as a binary dopant to reduce the cytotoxic effect of Zn2+. The nanosized HA powder was synthesized by the hydrothermal method and then heat-treated at 600 degrees C for 4 h. The heat-treated powder was plasma-sprayed on a titanium alloy Ti-6Al-4V substrate. The addition of the dopant did not significantly influence the physical and mechanical properties of the coating. However, the cytocompatibility, antimicrobial, and contact-angle properties statistically enhanced. Moreover, the (Sr,Zn)-HA coating was post-heat treated at 500 and 600 degrees C for 3 h. X-ray diffraction confirmed that after heat treatment phase purity and crystallinity increased and residual stress decreased. Mechanical stability was evaluated by adhesive bond strength, and the results showed that after heat-treatment bonding strength increased from 26.81 +/- 2.93 to 29.84 +/- 3.62 and 34.66 +/- 2.57 MPa, at 500 and 600 degrees C, respectively. Similar to the mechanical property, antibacterial activities and biological functions are also significantly improved. More interestingly, it was also observed that the Zn2+ ions released from the coating depend on Ca2+, P, and Sr2+ ions while Ca2+, P, and Sr2+ ions relied on heat treatment temperatures. However, (Sr,Zn)-HA coating at 600 degrees C demonstrates cytotoxic effects on MC3T3-E1 cells, characterized by poor cellular morphology on the coating surface and ultimately, cell death. The doping of Sr2+ with Zn2+, therefore, can offset the cytotoxic effects and enhanced biological performance. All of the outcomes of this study signify that (Sr,Zn)-HA coating heat-treated at 500 degrees C showed not only excellent mechanical and biological performance but also enhanced the antibacterial properties.
关键词	HA coating plasma spray heat treatment antibacterial properties biocompatibility
资助者	National Key Research and Development Program of China ; National Natural Science Foundation ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program-Top Young Talents
DOI	10.1021/acsbiomaterials.9b01396
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program-Top Young Talents[XLYC1807069]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000519150300005
出版者	AMER CHEMICAL SOC
引用统计	被引频次：68[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/137834
专题	中国科学院金属研究所
通讯作者	Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Ullah, Ihsan,Siddiqui, Muhammad Ali,Liu, Hui,et al. Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(3):1355-1366.
APA	Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Liu, Hui.,Kolawole, Sharafadeen Kunle.,Zhang, Ji.,...&Yang, Ke.(2020).Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(3),1355-1366.
MLA	Ullah, Ihsan,et al."Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.3(2020):1355-1366.