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Novel injectable and self-setting composite materials for bone defect repair
Xu, Qian1,2; Liang, Jiulong3; Xue, Haipeng3; Liu, Yun'en3; Cao, Lei2,4; Li, Xiaowu1; Tian, Jing3; Zhang, Xing2,4
Corresponding AuthorLi, Xiaowu(xwli@mail.neu.edu.cn) ; Tian, Jing(soldier_chn@163.com) ; Zhang, Xing(xingzhang@imr.ac.cn)
2020-05-01
Source PublicationSCIENCE CHINA-MATERIALS
ISSN2095-8226
Volume63Issue:5Pages:876-887
AbstractAlthough calcium sulfate bone cements possess favorable characteristics of excellent clinical handling and osteoconductivity, the rapid degradation and poor bioactivity limit their wide applications. This study reports a type of novel injectable and self-setting composite materials for bone defect repair. Magnesium substituted tricalcium phosphate nanoparticles (43.8 +/- 9.0 nm) and calcium sulfate hemihydrate micro-size particles (5-21 mu m) were mixed with a polyvinyl alcohol solution with optimal compositions to obtain the composite materials, which showed reasonable initial setting time (11.7-19.2 min) and suitable compressed strength (2.28-6.33 MPa). By utilizing magnesium powder as a porogen, macro-pores (>100 mu m) together with micro-pores were created in the final product after setting. In addition, MC3T3E1 cells extended well and exhibited numerous lamellipodia and long filopodia when cultured with the composite materials, indicating that they had no cytotoxicity. The in vivo results indicated that the injectable composite materials could achieve bone defect repair, when implanted in beagle femoral condyle defects for 10 months. Our results show that the new injectable composite materials are biocompatible and biodegradable, which possess great potential for bone defect repair.
Keywordnanoparticles magnesium substitution injectable materials self-setting bone defect repair
Funding OrganizationKey Research Program of Frontier Sciences ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province ; Liaoning Science and Technology Project ; Shenyang Key R&D and Technology Transfer Program
DOI10.1007/s40843-019-1233-7
Indexed BySCI
Language英语
Funding ProjectKey Research Program of Frontier Sciences[QYZDY-SSW-JSC031] ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province[201703031] ; Liaoning Science and Technology Project[20170540972] ; Shenyang Key R&D and Technology Transfer Program[Z17-7-023]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000528009400019
PublisherSCIENCE PRESS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/138444
Collection中国科学院金属研究所
Corresponding AuthorLi, Xiaowu; Tian, Jing; Zhang, Xing
Affiliation1.Northeastern Univ, Minist Educ, Key Lab Anisotropy & Texture Mat, Sch Mat Sci & Engn,Dept Mat Phys & Chem, Shenyang 110819, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Gen Hosp Northern Theater Command, Shenyang 110016, Peoples R China
4.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qian,Liang, Jiulong,Xue, Haipeng,et al. Novel injectable and self-setting composite materials for bone defect repair[J]. SCIENCE CHINA-MATERIALS,2020,63(5):876-887.
APA Xu, Qian.,Liang, Jiulong.,Xue, Haipeng.,Liu, Yun'en.,Cao, Lei.,...&Zhang, Xing.(2020).Novel injectable and self-setting composite materials for bone defect repair.SCIENCE CHINA-MATERIALS,63(5),876-887.
MLA Xu, Qian,et al."Novel injectable and self-setting composite materials for bone defect repair".SCIENCE CHINA-MATERIALS 63.5(2020):876-887.
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