Novel injectable and self-setting composite materials for bone defect repair

doi:10.1007/s40843-019-1233-7

IMR OpenIR

	Novel injectable and self-setting composite materials for bone defect repair
	Xu, Qian 1,2; Liang, Jiulong 3; Xue, Haipeng 3; Liu, Yun'en 3; Cao, Lei 2,4; Li, Xiaowu 1; Tian, Jing 3; Zhang, Xing 2,4
通讯作者	Li, Xiaowu(xwli@mail.neu.edu.cn) ; Tian, Jing(soldier_chn@163.com) ; Zhang, Xing(xingzhang@imr.ac.cn)
	2020-05-01
发表期刊	SCIENCE CHINA-MATERIALS
ISSN	2095-8226
卷号	63 期号:5 页码:876-887
摘要	Although calcium sulfate bone cements possess favorable characteristics of excellent clinical handling and osteoconductivity, the rapid degradation and poor bioactivity limit their wide applications. This study reports a type of novel injectable and self-setting composite materials for bone defect repair. Magnesium substituted tricalcium phosphate nanoparticles (43.8 +/- 9.0 nm) and calcium sulfate hemihydrate micro-size particles (5-21 mu m) were mixed with a polyvinyl alcohol solution with optimal compositions to obtain the composite materials, which showed reasonable initial setting time (11.7-19.2 min) and suitable compressed strength (2.28-6.33 MPa). By utilizing magnesium powder as a porogen, macro-pores (>100 mu m) together with micro-pores were created in the final product after setting. In addition, MC3T3E1 cells extended well and exhibited numerous lamellipodia and long filopodia when cultured with the composite materials, indicating that they had no cytotoxicity. The in vivo results indicated that the injectable composite materials could achieve bone defect repair, when implanted in beagle femoral condyle defects for 10 months. Our results show that the new injectable composite materials are biocompatible and biodegradable, which possess great potential for bone defect repair.
关键词	nanoparticles magnesium substitution injectable materials self-setting bone defect repair
资助者	Key Research Program of Frontier Sciences ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province ; Liaoning Science and Technology Project ; Shenyang Key R&D and Technology Transfer Program
DOI	10.1007/s40843-019-1233-7
收录类别	SCI
语种	英语
资助项目	Key Research Program of Frontier Sciences[QYZDY-SSW-JSC031] ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province[201703031] ; Liaoning Science and Technology Project[20170540972] ; Shenyang Key R&D and Technology Transfer Program[Z17-7-023]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000528009400019
出版者	SCIENCE PRESS
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/138444
专题	中国科学院金属研究所
通讯作者	Li, Xiaowu; Tian, Jing; Zhang, Xing
作者单位	1.Northeastern Univ, Minist Educ, Key Lab Anisotropy & Texture Mat, Sch Mat Sci & Engn,Dept Mat Phys & Chem, Shenyang 110819, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Gen Hosp Northern Theater Command, Shenyang 110016, Peoples R China 4.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Xu, Qian,Liang, Jiulong,Xue, Haipeng,et al. Novel injectable and self-setting composite materials for bone defect repair[J]. SCIENCE CHINA-MATERIALS,2020,63(5):876-887.
APA	Xu, Qian.,Liang, Jiulong.,Xue, Haipeng.,Liu, Yun'en.,Cao, Lei.,...&Zhang, Xing.(2020).Novel injectable and self-setting composite materials for bone defect repair.SCIENCE CHINA-MATERIALS,63(5),876-887.
MLA	Xu, Qian,et al."Novel injectable and self-setting composite materials for bone defect repair".SCIENCE CHINA-MATERIALS 63.5(2020):876-887.