IMR OpenIR
Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter
Wang, Lirong1; Erisen, Deniz E.2,3; Yang, Ke2; Zhang, Bingchun2; Guan, Hongyu1; Chen, Shanshan2
Corresponding AuthorGuan, Hongyu(guanhongyu@lnu.edu.cn) ; Chen, Shanshan(sschen@imr.ac.cn)
2020-05-18
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN1552-4973
Volume108Issue:7Pages:10
AbstractVascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi-biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu-bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti-infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti-infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti-infection property. The surface properties and Cu ions release behavior of Cu-bearing coating revealed the reasons for multi-biofunctions. This study indicated that the Cu-bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti-infection functions, which has excellent potential for clinical application.
Keywordantibacterial anticoagulation functional coating surface property vascular device
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences
DOI10.1002/jbm.b.34618
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFC1102404] ; National Key Research and Development Program of China[2018YFC1105504] ; National Natural Science Foundation of China[51901227] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000533382800001
PublisherWILEY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/138796
Collection中国科学院金属研究所
Corresponding AuthorGuan, Hongyu; Chen, Shanshan
Affiliation1.Liaoning Univ, Coll Chem, Chongshan Rd 66, Shenyang 110036, Peoples R China
2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
3.Univ Sci & Technol China, Hefei, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lirong,Erisen, Deniz E.,Yang, Ke,et al. Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2020,108(7):10.
APA Wang, Lirong,Erisen, Deniz E.,Yang, Ke,Zhang, Bingchun,Guan, Hongyu,&Chen, Shanshan.(2020).Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,108(7),10.
MLA Wang, Lirong,et al."Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 108.7(2020):10.
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