Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

doi:10.1002/jbm.b.34618

IMR OpenIR

	Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter
	Wang, Lirong 1; Erisen, Deniz E.2,3; Yang, Ke 2; Zhang, Bingchun 2; Guan, Hongyu 1; Chen, Shanshan 2
通讯作者	Guan, Hongyu(guanhongyu@lnu.edu.cn) ; Chen, Shanshan(sschen@imr.ac.cn)
	2020-05-18
发表期刊	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN	1552-4973
卷号	108 期号:7 页码:10
摘要	Vascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi-biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu-bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti-infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti-infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti-infection property. The surface properties and Cu ions release behavior of Cu-bearing coating revealed the reasons for multi-biofunctions. This study indicated that the Cu-bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti-infection functions, which has excellent potential for clinical application.
关键词	antibacterial anticoagulation functional coating surface property vascular device
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences
DOI	10.1002/jbm.b.34618
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC1102404] ; National Key Research and Development Program of China[2018YFC1105504] ; National Natural Science Foundation of China[51901227] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000533382800001
出版者	WILEY
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/138796
专题	中国科学院金属研究所
通讯作者	Guan, Hongyu; Chen, Shanshan
作者单位	1.Liaoning Univ, Coll Chem, Chongshan Rd 66, Shenyang 110036, Peoples R China 2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lirong,Erisen, Deniz E.,Yang, Ke,et al. Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2020,108(7):10.
APA	Wang, Lirong,Erisen, Deniz E.,Yang, Ke,Zhang, Bingchun,Guan, Hongyu,&Chen, Shanshan.(2020).Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,108(7),10.
MLA	Wang, Lirong,et al."Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 108.7(2020):10.