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Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity
Liu, Hui1,2; Liu, Rui2,3; Ullah, Ihsan1,2; Zhang, Shuyuan2; Sun, Ziqing2; Ren, Ling2; Yang, Ke2
Corresponding AuthorRen, Ling(lren@imr.ac.cn)
2020-07-01
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume48Pages:130-139
AbstractImplant-related infection and early bone integration are the main risk factors of implants for long-term service, to overcome these difficulties, SLA-TiCu surface was prepared by sandblasting and large-grits etching (SLA) treatment on a novel antibacterial titanium-copper alloy (TiCu), which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants. Effects of SLA-TiCu surface on the adhesion, proliferation, apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen (Staphylococcus aureus) were studied. Compared to the following surfaces: sandblasting and large-grits etched pure titanium (SLA-Ti), mechanically ground pure titanium and TiCu alloy (M-Ti and M-TiCu), these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions (alkaline phosphates (ALP), collagen type I (COL I), Runt-related transcription factor 2 (RUN x 2), and osteopontin (OPN)). Moreover, SLA-TiCu surface could maintain a sustainable release of Cu2+ ions and effectively inhibited the viability of bacteria. This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity, making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordTitanium Copper Roughness surface Osteogenesis Antibacterial
Funding OrganizationNational Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences
DOI10.1016/j.jmst.2019.12.019
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100601] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB2018000]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000534323200017
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/138963
Collection中国科学院金属研究所
Corresponding AuthorRen, Ling
Affiliation1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China
3.Renji Hosp, State Key Lab Oncogenes & Related Genes, Inst Mol Med, 160 Pujian Rd, Shanghai 220127, Peoples R China
Recommended Citation
GB/T 7714
Liu, Hui,Liu, Rui,Ullah, Ihsan,et al. Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,48:130-139.
APA Liu, Hui.,Liu, Rui.,Ullah, Ihsan.,Zhang, Shuyuan.,Sun, Ziqing.,...&Yang, Ke.(2020).Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,48,130-139.
MLA Liu, Hui,et al."Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 48(2020):130-139.
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