Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application

doi:10.1016/j.ceramint.2020.02.242

IMR OpenIR

	Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application
	Ullah, Ihsan 1,2; Siddiqui, Muhammad Ali 1,2,3; Kolawole, Sharafadeen Kunle 1,2; Liu, Hui 1,2; Zhang, Ji 1; Ren, Ling 1; Yang, Ke 1
通讯作者	Ren, Ling(lren@imr.ac.cn)
	2020-07-01
发表期刊	CERAMICS INTERNATIONAL
ISSN	0272-8842
卷号	46 期号:10 页码:14448-14459
摘要	The aim of the present study is to examine the function of the two significant biological cations, Zn2+ and Sr2+, when co-doped in the structure of hydroxyapatite (HA). Six samples with different Zn2+ and Sr2+ concentrations were prepared by a hydrothermal process that includes the addition of Zn2+ and Sr2+ containing precursors to replace Ca2+ partially in the HA structure. The obtained nanomaterials were examined via XRD, ICP, FTIR, Raman spectroscopy, FESEM, TEM, and TGA for the investigation and confirmation of co-doping, crystallinity, phase purity, lattice parameters, elemental compositions, particle morphology, and thermal stability respectively. Interestingly the Zn2+ substitution increase with Sr2+ co-doping and the apatite structure going disappear up to 20% Zn10%Sr or 10%Zn20%Sr in the solution. Furthermore, in vitro cell viability even at high Zn2+ concentration (up to 6 wt %), MC3T3-E1 cells proliferated at a high rate on co-substituted HA materials, confirming that Sr2+ offset the cytotoxic effect of Zn2+ and increased the biocompatibility of the material. Moreover, the antibacterial effects of co-substituted HA against pathogen bacterial strains (E.coli and S.aureus) were also significantly increased. Overall results demonstrated that HA co-substituted by Zn2+ and Sr2+ at (10% Zn10%Sr-HA) is a potential material for hard tissue scaffolds.
关键词	Co-substituted hydroxyapatite Structural characterization In vitro bioactivity Antibacterial
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program -Top Young Talents
DOI	10.1016/j.ceramint.2020.02.242
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program -Top Young Talents[XLYC1807069]
WOS研究方向	Materials Science
WOS类目	Materials Science, Ceramics
WOS记录号	WOS:000533511200013
出版者	ELSEVIER SCI LTD
引用统计	被引频次：64[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/139030
专题	中国科学院金属研究所
通讯作者	Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 3.NED Univ Engn & Technol, Dept Met Engn, Karachi, Pakistan
推荐引用方式 GB/T 7714	Ullah, Ihsan,Siddiqui, Muhammad Ali,Kolawole, Sharafadeen Kunle,et al. Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application[J]. CERAMICS INTERNATIONAL,2020,46(10):14448-14459.
APA	Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Kolawole, Sharafadeen Kunle.,Liu, Hui.,Zhang, Ji.,...&Yang, Ke.(2020).Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application.CERAMICS INTERNATIONAL,46(10),14448-14459.
MLA	Ullah, Ihsan,et al."Synthesis, characterization and in vitro evaluation of zinc and strontium binary doped hydroxyapatite for biomedical application".CERAMICS INTERNATIONAL 46.10(2020):14448-14459.