| Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods | |
| Zhan, Xinxin1,6; Li, Shujun2; Cui, Yuntao3; Tao, Anqi1; Wang, Chengcheng1; Li, Huazhi1; Zhang, Linlin4; Yu, Hanrong4; Jiang, Jiuhui1; Li, Cuiying5 | |
| Corresponding Author | Jiang, Jiuhui(drjiangw@163.com) ; Li, Cuiying(Licuiying_67@163.com) |
| 2020-08-01 | |
| Source Publication | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| ISSN | 0928-4931 |
| Volume | 113Pages:9 |
| Abstract | Ti-24Nb-4Zr-8Sn (Ti2448) alloy is a novel low elastic modulus beta-titanium alloy without toxic elements. It also has the advantage of high strength, so it has potential application prospects for implantation. To develop its osteogenic effects, it can be modified by electrochemical, and physical processes. The main research aim of this study was to explore the bioactivity of Ti2448 alloy modified by sandblasted, large-grit, acid-etched (SLA), micro-arc oxidation (MAO) and anodic oxidation (AO), and to determine which of the three surface modifications is the best way for developing the osteogenesis of bone marrow mesenchymal stem cells (BMMSCs). In vitro studies, the cytoskeleton, focal adhesion and proliferation of BMMSCs showed that both pure titanium and Ti2448 alloy have good biocompatibility. The osteogenic differentiation of BMMSCs with the Ti2448 alloy were examined by detecting alkaline phosphatase (ALP), mineralization nodules and osteogenic proteins and were better than that with pure titanium. These results showed that the Ti2448 alloy treated by SLA has a better effect on osteogenesis than pure titanium, and AO is the best way of three surface treatments to improve osteogenesis in this study. |
| Keyword | Low elastic modulus Ti-24Nb-4Zr-8Sn alloy Bioactivity of bone marrow mesenchymal stem cells Sandblasted, large-grit, acid-etched Micro-arc oxidation Anodic oxidation |
| Funding Organization | National Key Research and Development Program of China ; Key Research Program of Frontier Sciences, CAS |
| DOI | 10.1016/j.msec.2020.111018 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2016YFC1102603] ; Key Research Program of Frontier Sciences, CAS[QYZDJSSW-JSC031-02] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| WOS ID | WOS:000537712500017 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/139118 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Jiang, Jiuhui; Li, Cuiying |
| Affiliation | 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Titanium Alloy Lab, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen & Beijing Key Lab Cryobiomed, Beijing 100190, Peoples R China 4.Jiamusi Univ, Affiliated Stomatol, Dept Dent Implants, Jiamusi, Peoples R China 5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China 6.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Zhan, Xinxin,Li, Shujun,Cui, Yuntao,et al. Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,113:9. |
| APA | Zhan, Xinxin.,Li, Shujun.,Cui, Yuntao.,Tao, Anqi.,Wang, Chengcheng.,...&Li, Cuiying.(2020).Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,113,9. |
| MLA | Zhan, Xinxin,et al."Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 113(2020):9. |
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