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Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods
Zhan, Xinxin1,6; Li, Shujun2; Cui, Yuntao3; Tao, Anqi1; Wang, Chengcheng1; Li, Huazhi1; Zhang, Linlin4; Yu, Hanrong4; Jiang, Jiuhui1; Li, Cuiying5
Corresponding AuthorJiang, Jiuhui(drjiangw@163.com) ; Li, Cuiying(Licuiying_67@163.com)
2020-08-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume113Pages:9
AbstractTi-24Nb-4Zr-8Sn (Ti2448) alloy is a novel low elastic modulus beta-titanium alloy without toxic elements. It also has the advantage of high strength, so it has potential application prospects for implantation. To develop its osteogenic effects, it can be modified by electrochemical, and physical processes. The main research aim of this study was to explore the bioactivity of Ti2448 alloy modified by sandblasted, large-grit, acid-etched (SLA), micro-arc oxidation (MAO) and anodic oxidation (AO), and to determine which of the three surface modifications is the best way for developing the osteogenesis of bone marrow mesenchymal stem cells (BMMSCs). In vitro studies, the cytoskeleton, focal adhesion and proliferation of BMMSCs showed that both pure titanium and Ti2448 alloy have good biocompatibility. The osteogenic differentiation of BMMSCs with the Ti2448 alloy were examined by detecting alkaline phosphatase (ALP), mineralization nodules and osteogenic proteins and were better than that with pure titanium. These results showed that the Ti2448 alloy treated by SLA has a better effect on osteogenesis than pure titanium, and AO is the best way of three surface treatments to improve osteogenesis in this study.
KeywordLow elastic modulus Ti-24Nb-4Zr-8Sn alloy Bioactivity of bone marrow mesenchymal stem cells Sandblasted, large-grit, acid-etched Micro-arc oxidation Anodic oxidation
Funding OrganizationNational Key Research and Development Program of China ; Key Research Program of Frontier Sciences, CAS
DOI10.1016/j.msec.2020.111018
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFC1102603] ; Key Research Program of Frontier Sciences, CAS[QYZDJSSW-JSC031-02]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000537712500017
PublisherELSEVIER
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139118
Collection中国科学院金属研究所
Corresponding AuthorJiang, Jiuhui; Li, Cuiying
Affiliation1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Titanium Alloy Lab, 72 Wenhua Rd, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen & Beijing Key Lab Cryobiomed, Beijing 100190, Peoples R China
4.Jiamusi Univ, Affiliated Stomatol, Dept Dent Implants, Jiamusi, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China
6.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhan, Xinxin,Li, Shujun,Cui, Yuntao,et al. Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,113:9.
APA Zhan, Xinxin.,Li, Shujun.,Cui, Yuntao.,Tao, Anqi.,Wang, Chengcheng.,...&Li, Cuiying.(2020).Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,113,9.
MLA Zhan, Xinxin,et al."Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 113(2020):9.
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