Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods

doi:10.1016/j.msec.2020.111018

IMR OpenIR

	Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods
	Zhan, Xinxin 1,6; Li, Shujun 2; Cui, Yuntao 3; Tao, Anqi 1; Wang, Chengcheng 1; Li, Huazhi 1; Zhang, Linlin 4; Yu, Hanrong 4; Jiang, Jiuhui 1; Li, Cuiying 5
通讯作者	Jiang, Jiuhui(drjiangw@163.com) ; Li, Cuiying(Licuiying_67@163.com)
	2020-08-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	113 页码:9
摘要	Ti-24Nb-4Zr-8Sn (Ti2448) alloy is a novel low elastic modulus beta-titanium alloy without toxic elements. It also has the advantage of high strength, so it has potential application prospects for implantation. To develop its osteogenic effects, it can be modified by electrochemical, and physical processes. The main research aim of this study was to explore the bioactivity of Ti2448 alloy modified by sandblasted, large-grit, acid-etched (SLA), micro-arc oxidation (MAO) and anodic oxidation (AO), and to determine which of the three surface modifications is the best way for developing the osteogenesis of bone marrow mesenchymal stem cells (BMMSCs). In vitro studies, the cytoskeleton, focal adhesion and proliferation of BMMSCs showed that both pure titanium and Ti2448 alloy have good biocompatibility. The osteogenic differentiation of BMMSCs with the Ti2448 alloy were examined by detecting alkaline phosphatase (ALP), mineralization nodules and osteogenic proteins and were better than that with pure titanium. These results showed that the Ti2448 alloy treated by SLA has a better effect on osteogenesis than pure titanium, and AO is the best way of three surface treatments to improve osteogenesis in this study.
关键词	Low elastic modulus Ti-24Nb-4Zr-8Sn alloy Bioactivity of bone marrow mesenchymal stem cells Sandblasted, large-grit, acid-etched Micro-arc oxidation Anodic oxidation
资助者	National Key Research and Development Program of China ; Key Research Program of Frontier Sciences, CAS
DOI	10.1016/j.msec.2020.111018
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC1102603] ; Key Research Program of Frontier Sciences, CAS[QYZDJSSW-JSC031-02]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000537712500017
出版者	ELSEVIER
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/139118
专题	中国科学院金属研究所
通讯作者	Jiang, Jiuhui; Li, Cuiying
作者单位	1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Titanium Alloy Lab, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen & Beijing Key Lab Cryobiomed, Beijing 100190, Peoples R China 4.Jiamusi Univ, Affiliated Stomatol, Dept Dent Implants, Jiamusi, Peoples R China 5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China 6.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Xinxin,Li, Shujun,Cui, Yuntao,et al. Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,113:9.
APA	Zhan, Xinxin.,Li, Shujun.,Cui, Yuntao.,Tao, Anqi.,Wang, Chengcheng.,...&Li, Cuiying.(2020).Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,113,9.
MLA	Zhan, Xinxin,et al."Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 113(2020):9.