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Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants
Chen, Shanshan2; Wan, Peng3; Zhang, Bingchun2; Yang, Ke2; Li, Yuhai1
Corresponding AuthorWan, Peng(wanpeng@dgut.edu.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Li, Yuhai(yuhai_li@qq.com)
2020-05-01
Source PublicationJOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN2214-031X
Volume22Pages:2-6
AbstractBackground: Bisphosphonates (BPs) are known as a group of well-established drugs which are clinically used in metabolic bone disorder-related therapies. Recently increasing interests are focused on the application of BPs in the biodegradable Mg-based implants. Methods: In this study a facile method was applied to fabricate a zoledronate loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca-P chelation with BPs. Results: The results showed that the fluoride pretreated coating could provide better corrosion resistance. Zoledronic acid (ZA) was successfully loaded on the surface of Mg alloy detected by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) analysis, and the release profile was quantified with Ultraviolet (UV) detection. Conclusion: It is considered that this construction of ZA coated Mg-based orthopedic implants could be easily and efficiently used in clinic. The translational potential of this article: Different from the traditional drug release mode, this paper used the hydrogen bond between drug molecules and drug carriers to not only realise the effective drug release in the early stage of drug release, but also meet the continuous effect of drugs in the later stage, providing a new possibility for clinical application.
KeywordBiodegradable Drug loading Magnesium alloy Orthopaedic implant Zoledronate
Funding Organizationopen fund of characteristic training discipline of Shenyang Ligong University ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; doctoral scientific research fund of Dongguan University of Technology
DOI10.1016/j.jot.2019.09.007
Indexed BySCI
Language英语
Funding Projectopen fund of characteristic training discipline of Shenyang Ligong University[0101311008502] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194] ; doctoral scientific research fund of Dongguan University of Technology[GC300501-082]
WOS Research AreaOrthopedics
WOS SubjectOrthopedics
WOS IDWOS:000536593000002
PublisherELSEVIER
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139139
Collection中国科学院金属研究所
Corresponding AuthorWan, Peng; Yang, Ke; Li, Yuhai
Affiliation1.Shenyang Ligong Univ, Sch Mat, Shenyang 110168, Peoples R China
2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
3.Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China
Recommended Citation
GB/T 7714
Chen, Shanshan,Wan, Peng,Zhang, Bingchun,et al. Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2020,22:2-6.
APA Chen, Shanshan,Wan, Peng,Zhang, Bingchun,Yang, Ke,&Li, Yuhai.(2020).Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants.JOURNAL OF ORTHOPAEDIC TRANSLATION,22,2-6.
MLA Chen, Shanshan,et al."Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants".JOURNAL OF ORTHOPAEDIC TRANSLATION 22(2020):2-6.
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