Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants

doi:10.1016/j.jot.2019.09.007

IMR OpenIR

	Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants
	Chen, Shanshan 2; Wan, Peng 3; Zhang, Bingchun 2; Yang, Ke 2; Li, Yuhai 1
通讯作者	Wan, Peng(wanpeng@dgut.edu.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Li, Yuhai(yuhai_li@qq.com)
	2020-05-01
发表期刊	JOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN	2214-031X
卷号	22 页码:2-6
摘要	Background: Bisphosphonates (BPs) are known as a group of well-established drugs which are clinically used in metabolic bone disorder-related therapies. Recently increasing interests are focused on the application of BPs in the biodegradable Mg-based implants. Methods: In this study a facile method was applied to fabricate a zoledronate loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca-P chelation with BPs. Results: The results showed that the fluoride pretreated coating could provide better corrosion resistance. Zoledronic acid (ZA) was successfully loaded on the surface of Mg alloy detected by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) analysis, and the release profile was quantified with Ultraviolet (UV) detection. Conclusion: It is considered that this construction of ZA coated Mg-based orthopedic implants could be easily and efficiently used in clinic. The translational potential of this article: Different from the traditional drug release mode, this paper used the hydrogen bond between drug molecules and drug carriers to not only realise the effective drug release in the early stage of drug release, but also meet the continuous effect of drugs in the later stage, providing a new possibility for clinical application.
关键词	Biodegradable Drug loading Magnesium alloy Orthopaedic implant Zoledronate
资助者	open fund of characteristic training discipline of Shenyang Ligong University ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; doctoral scientific research fund of Dongguan University of Technology
DOI	10.1016/j.jot.2019.09.007
收录类别	SCI
语种	英语
资助项目	open fund of characteristic training discipline of Shenyang Ligong University[0101311008502] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194] ; doctoral scientific research fund of Dongguan University of Technology[GC300501-082]
WOS研究方向	Orthopedics
WOS类目	Orthopedics
WOS记录号	WOS:000536593000002
出版者	ELSEVIER
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/139139
专题	中国科学院金属研究所
通讯作者	Wan, Peng; Yang, Ke; Li, Yuhai
作者单位	1.Shenyang Ligong Univ, Sch Mat, Shenyang 110168, Peoples R China 2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China
推荐引用方式 GB/T 7714	Chen, Shanshan,Wan, Peng,Zhang, Bingchun,et al. Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2020,22:2-6.
APA	Chen, Shanshan,Wan, Peng,Zhang, Bingchun,Yang, Ke,&Li, Yuhai.(2020).Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants.JOURNAL OF ORTHOPAEDIC TRANSLATION,22,2-6.
MLA	Chen, Shanshan,et al."Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants".JOURNAL OF ORTHOPAEDIC TRANSLATION 22(2020):2-6.