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Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration
Cai, Bianyun1; Tan, Peijie2,3,4; Jiang, Nan2,3,4; Guo, Zhijun5; Ay, Birol6; Li, Shujun7; Hou, Yi1; Li, Yubao1; You, Yanjun8; Zhang, Li1,2,3,4; Zhu, Songsong2,3,4
Corresponding AuthorZhang, Li(zhangli9111@126.com) ; Zhu, Songsong(zss_1977@163.com)
2020-06-01
Source PublicationBIOCONJUGATE CHEMISTRY
ISSN1043-1802
Volume31Issue:6Pages:1641-1650
AbstractBioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The in vitro studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared in vivo, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Key Research of Frontier Sciences, CAS
DOI10.1021/acs.bioconjchem.0c00201
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[51673131] ; National Natural Science Foundation of China[51871220] ; National Key Research and Development Program of China[2016YFA0201703] ; Key Research of Frontier Sciences, CAS[QYZDJ-SSW-JSC031-02]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS IDWOS:000542926300008
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139459
Collection中国科学院金属研究所
Corresponding AuthorZhang, Li; Zhu, Songsong
Affiliation1.Sichuan Univ, Analyt & Testing Ctr, Chengdu 610065, Peoples R China
2.Sichuan Univ, State Key Lab Oral Dis, Chengdu 610065, Peoples R China
3.Sichuan Univ, Natl Clin Res Ctr Oral Dis, Chengdu 610065, Peoples R China
4.Sichuan Univ, West China Hosp Stomatol, Chengdu 610065, Peoples R China
5.China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China
6.Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
7.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
8.Sichuan Inst Food & Drug Control, Chengdu 610065, Peoples R China
Recommended Citation
GB/T 7714
Cai, Bianyun,Tan, Peijie,Jiang, Nan,et al. Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration[J]. BIOCONJUGATE CHEMISTRY,2020,31(6):1641-1650.
APA Cai, Bianyun.,Tan, Peijie.,Jiang, Nan.,Guo, Zhijun.,Ay, Birol.,...&Zhu, Songsong.(2020).Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.BIOCONJUGATE CHEMISTRY,31(6),1641-1650.
MLA Cai, Bianyun,et al."Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration".BIOCONJUGATE CHEMISTRY 31.6(2020):1641-1650.
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