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Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface
Wang, Wei1; Wang, Zhenbo2; Fu, Yating1; Dunne, Nicholas3; Liang, Chen2; Luo, Xue1; Liu, Keda1; Li, Xiaoming4,5; Pang, Xining1,6; Lu, Ke2
Corresponding AuthorWang, Zhenbo(zbwang@imr.ac.cn) ; Li, Xiaoming(x.m.li@hotmail.com) ; Pang, Xining(pangxining@126.com)
2020-09-01
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume108Issue:9Pages:1824-1833
AbstractTitanium (Ti) and Ti-based alloys are widely used in the manufacture of dental and orthopedic implants. However, how to improve their osteogenic differentiation ability is still a key issue to be resolved. In this study, gradient nanostructured surface (GNS) samples were prepared by surface mechanical grinding treatment, and coarse-grained (CG) samples were obtained by recrystallization annealing, making sure that the two kinds of specimens had similar roughness. Then, human amniotic mesenchymal stem cells (hAMSCs) were cocultured with the two kinds of Ti to investigate the material effects on the cellular functions. The results demonstrated that the grains with size similar to 56 nm were formed on the surface of the GNS Ti, and the grain size gradually increases from the sample surface to interior. Compared to the CG samples, the GNS ones could make the adhesion effect of the hAMSCs better, and promote the cell proliferation and osteogenic differentiation more significantly, the preliminary mechanism of which might be due to their specific nanostructure, the thicker oxide layer formed on their surface and the enhanced hardness. Our results indicated that the gradient nanostructured Ti materials could enhance both osteogenic differentiation and mechanical properties, which may possess broader applications in bone tissue engineering and clinical implanting.
Keywordgradient nanostructured human amniotic mesenchymal stem cells osteogenic differentiation surface mechanical attrition treatment titanium (Ti)
Funding OrganizationLiaoning Provincial Natural Science Foundation Guidance Project ; Central Government of Liaoning Province to Guide Local Science and Technology Development Project ; International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China ; 111 Project ; Liaoning Province, Colleges and Universities Basic Research Project ; Liaoning Provincial Key Research Plan Guidance Project ; National Natural Science Foundation of China ; Shenyang Major Scientific and Technological Innovation Research and Development Plan ; Second Batch of Medical Education Scientific Research Projects of the 13th Five-Year Plan of China Medical University
DOI10.1002/jbm.a.36948
Indexed BySCI
Language英语
Funding ProjectLiaoning Provincial Natural Science Foundation Guidance Project[2019-ZD-0749] ; Central Government of Liaoning Province to Guide Local Science and Technology Development Project[2017108001] ; International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China[B13003] ; 111 Project[B13003] ; Liaoning Province, Colleges and Universities Basic Research Project[LFWK201717] ; Liaoning Provincial Key Research Plan Guidance Project[2018225078] ; National Natural Science Foundation of China[31771042] ; National Natural Science Foundation of China[81970980] ; Shenyang Major Scientific and Technological Innovation Research and Development Plan[19-112-4-027] ; Second Batch of Medical Education Scientific Research Projects of the 13th Five-Year Plan of China Medical University[YDJK2018017]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000541582000001
PublisherWILEY
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139532
Collection中国科学院金属研究所
Corresponding AuthorWang, Zhenbo; Li, Xiaoming; Pang, Xining
Affiliation1.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Liaoning, Peoples R China
2.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
3.Dublin City Univ, Sch Mech & Mfg Engn, Ctr Med Engn Res, Dublin, Ireland
4.Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing 100083, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing, Peoples R China
6.China Med Univ, Key Lab Cell Biol, Shenyang, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Wang, Wei,Wang, Zhenbo,Fu, Yating,et al. Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2020,108(9):1824-1833.
APA Wang, Wei.,Wang, Zhenbo.,Fu, Yating.,Dunne, Nicholas.,Liang, Chen.,...&Lu, Ke.(2020).Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,108(9),1824-1833.
MLA Wang, Wei,et al."Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 108.9(2020):1824-1833.
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