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Effect of Gradient Nanostructured Ti on Behaviours of MG63 Cells In Vitro
Luo, Xue1; Liang, Chen2; Li, Ning3; Zhu, Yuhe1; Cao, Nanjue4; Wang, Jin1; Liu, Keda1; Zhao, Hongwei3; Wang, Zhenbo2; Wang, Wei1
Corresponding AuthorZhao, Hongwei(13931386052@163.com) ; Wang, Zhenbo(zbwang@imr.ac.cn) ; Wang, Wei(wwang75@cmu.edu.cn)
2020-06-05
Source PublicationJOURNAL OF NANOMATERIALS
ISSN1687-4110
Volume2020Pages:11
AbstractTitanium (Ti) is widely used in oral implants. However, there is still a challenge to promote the osseointegration of bone tissue on the surface of Ti. To solve this problem, we prepared novel gradient nanostructured (GNS) Ti and studied the effect of GNS on the adhesion, proliferation, and apoptosis of MG63 cellsin vitro. The results demonstrated that the GNS Ti promoted the adhesion effect and proliferation of MG63 cells better than the annealed Ti, while the ability of GNS Ti to inhibit cell apoptosis was better than that of the annealed Ti, the preliminary mechanism of which indicated by this study might be the enhanced mineralization capacity, protein adsorption ability, and hydrophilicity of the GNS Ti due to its specific nanostructure which improved the cell behaviours. The results in this study provide the theoretical and experimental foundations for the applications of GNS Ti in dental implants and joint replacements.
Funding OrganizationNational Natural Science Foundation of China ; Liaoning Provincial Key Research Plan Guidance Project ; Liaoning Provincial Natural Science Foundation Guidance Project ; Liaoning Province, Colleges and Universities Basic Research Project ; Central Government of Liaoning Province to Guide Local Science and Technology Development Project ; Shenyang Major Scientific and Technological Innovation Research and Development Plan ; Second Batch of Medical Education Scientific Research Projects of the 13th Five-Year Plan of China Medical University
DOI10.1155/2020/9480537
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81970980] ; Liaoning Provincial Key Research Plan Guidance Project[2018225078] ; Liaoning Provincial Natural Science Foundation Guidance Project[2019-ZD-0749] ; Liaoning Province, Colleges and Universities Basic Research Project[LFWK201717] ; Central Government of Liaoning Province to Guide Local Science and Technology Development Project[2017108001] ; Shenyang Major Scientific and Technological Innovation Research and Development Plan[19-112-4-027] ; Second Batch of Medical Education Scientific Research Projects of the 13th Five-Year Plan of China Medical University[YDJK2018017]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000548802600001
PublisherHINDAWI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/139824
Collection中国科学院金属研究所
Corresponding AuthorZhao, Hongwei; Wang, Zhenbo; Wang, Wei
Affiliation1.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China
2.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Fourth Cent Hosp Baoding City, Dept Orthoped, Baoding 072350, Peoples R China
4.Zhejiang Univ, Affiliated Hosp 4, Sch Med, Yiwu 322000, Peoples R China
Recommended Citation
GB/T 7714
Luo, Xue,Liang, Chen,Li, Ning,et al. Effect of Gradient Nanostructured Ti on Behaviours of MG63 Cells In Vitro[J]. JOURNAL OF NANOMATERIALS,2020,2020:11.
APA Luo, Xue.,Liang, Chen.,Li, Ning.,Zhu, Yuhe.,Cao, Nanjue.,...&Wang, Wei.(2020).Effect of Gradient Nanostructured Ti on Behaviours of MG63 Cells In Vitro.JOURNAL OF NANOMATERIALS,2020,11.
MLA Luo, Xue,et al."Effect of Gradient Nanostructured Ti on Behaviours of MG63 Cells In Vitro".JOURNAL OF NANOMATERIALS 2020(2020):11.
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