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Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing
Zhang, Wenchang1,2; Qi, Xiaomin3; Zhao, Yan1; Liu, Yunen4; Xu, Lei1; Song, Xiaoqiang1,2; Xiao, Chenjuan1,2; Yuan, Xiaoxue1,2; Zhang, Jinsong1; Hou, Mingxiao4
Corresponding AuthorZhao, Yan(yanzhao@imr.ac.cn) ; Liu, Yunen(cszx_lye@163.com) ; Zhang, Jinsong(jshzhang@imr.ac.cn)
2020-08-30
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume586Pages:13
AbstractInjectable hydrogels with high anti-inflammatory and wound-healing properties are highly desirable for clinical application. In the present study, injectable hydrogels were prepared based on carboxymethyl chitosan and oxidized hyaluronic acid. Blueberry anthocyanins (BA), which are known for their antioxidant and antiinflammatory properties, were successfully loaded into the hydrogels. The gelation kinetics and mechanical properties of the hydrogels were investigated. Oxidized hyaluronic acid with an oxidation degree of 38.1% conferred a suitable gelation time (similar to 70 s) and mechanical properties (76.0 kPa compression stress at strain of 80%) of the hydrogel. The injectable BA-loaded hydrogel significantly accelerated the wound healing process in a full-thickness skin wound model in rats, promoted epithelial and tissue regeneration, exerted antiinflammatory effects, and promoted collagen deposition and angiogenesis. Besides, the hydrogel could upregulate the expression of VEGF and IL-10 proteins, downregulate the NF-kappa B level, and promote macrophage transformation from M1 phenotype to M2. The promotion of the BA-loaded hydrogel on wound healing were mainly realized by its biological effects, including antioxidant and anti-inflammatory effects, and regulation of various wound healing related factors. The results suggested that BA and the hydrogels exert synergistic effects in promoting wound healing. Injectable BA-loaded hydrogels appear to be promising candidates for wound healing application.
KeywordInjectable hydrogel Blueberry anthocyanins Carboxymethyl chitosan Oxidized hyaluronic acid Wound healing
Funding OrganizationNational Natural Science Foundation of China
DOI10.1016/j.ijpharm.2020.119543
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U1608255]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000557910700002
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140148
Collection中国科学院金属研究所
Corresponding AuthorZhao, Yan; Liu, Yunen; Zhang, Jinsong
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
3.Peoples Hosp Liaoning Prov, Shenyang 110016, Peoples R China
4.Northern Theater Command, Emergency Med, Dept Gen Hosp, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wenchang,Qi, Xiaomin,Zhao, Yan,et al. Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,586:13.
APA Zhang, Wenchang.,Qi, Xiaomin.,Zhao, Yan.,Liu, Yunen.,Xu, Lei.,...&Hou, Mingxiao.(2020).Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing.INTERNATIONAL JOURNAL OF PHARMACEUTICS,586,13.
MLA Zhang, Wenchang,et al."Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing".INTERNATIONAL JOURNAL OF PHARMACEUTICS 586(2020):13.
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