Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing

doi:10.1016/j.ijpharm.2020.119543

IMR OpenIR

	Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing
	Zhang, Wenchang 1,2; Qi, Xiaomin 3; Zhao, Yan 1; Liu, Yunen 4; Xu, Lei 1; Song, Xiaoqiang 1,2; Xiao, Chenjuan 1,2; Yuan, Xiaoxue 1,2; Zhang, Jinsong 1; Hou, Mingxiao 4
通讯作者	Zhao, Yan(yanzhao@imr.ac.cn) ; Liu, Yunen(cszx_lye@163.com) ; Zhang, Jinsong(jshzhang@imr.ac.cn)
	2020-08-30
发表期刊	INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN	0378-5173
卷号	586 页码:13
摘要	Injectable hydrogels with high anti-inflammatory and wound-healing properties are highly desirable for clinical application. In the present study, injectable hydrogels were prepared based on carboxymethyl chitosan and oxidized hyaluronic acid. Blueberry anthocyanins (BA), which are known for their antioxidant and antiinflammatory properties, were successfully loaded into the hydrogels. The gelation kinetics and mechanical properties of the hydrogels were investigated. Oxidized hyaluronic acid with an oxidation degree of 38.1% conferred a suitable gelation time (similar to 70 s) and mechanical properties (76.0 kPa compression stress at strain of 80%) of the hydrogel. The injectable BA-loaded hydrogel significantly accelerated the wound healing process in a full-thickness skin wound model in rats, promoted epithelial and tissue regeneration, exerted antiinflammatory effects, and promoted collagen deposition and angiogenesis. Besides, the hydrogel could upregulate the expression of VEGF and IL-10 proteins, downregulate the NF-kappa B level, and promote macrophage transformation from M1 phenotype to M2. The promotion of the BA-loaded hydrogel on wound healing were mainly realized by its biological effects, including antioxidant and anti-inflammatory effects, and regulation of various wound healing related factors. The results suggested that BA and the hydrogels exert synergistic effects in promoting wound healing. Injectable BA-loaded hydrogels appear to be promising candidates for wound healing application.
关键词	Injectable hydrogel Blueberry anthocyanins Carboxymethyl chitosan Oxidized hyaluronic acid Wound healing
资助者	National Natural Science Foundation of China
DOI	10.1016/j.ijpharm.2020.119543
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U1608255]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000557910700002
出版者	ELSEVIER
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/140148
专题	中国科学院金属研究所
通讯作者	Zhao, Yan; Liu, Yunen; Zhang, Jinsong
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Peoples Hosp Liaoning Prov, Shenyang 110016, Peoples R China 4.Northern Theater Command, Emergency Med, Dept Gen Hosp, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wenchang,Qi, Xiaomin,Zhao, Yan,et al. Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,586:13.
APA	Zhang, Wenchang.,Qi, Xiaomin.,Zhao, Yan.,Liu, Yunen.,Xu, Lei.,...&Hou, Mingxiao.(2020).Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing.INTERNATIONAL JOURNAL OF PHARMACEUTICS,586,13.
MLA	Zhang, Wenchang,et al."Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing".INTERNATIONAL JOURNAL OF PHARMACEUTICS 586(2020):13.