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Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects
Fan, Bo1,2; Guo, Zheng1; Li, Xiaokang1; Li, Songkai2; Gao, Peng3,4; Xiao, Xin1; Wu, Jie1; Shen, Chao1; Jiao, Yilai5; Hou, Wentao5
Corresponding AuthorGuo, Zheng(guozheng@fmmu.edu.cn)
2020-12-01
Source PublicationBIOACTIVE MATERIALS
Volume5Issue:4Pages:1087-1101
AbstractFor large segmental bone defects, porous titanium scaffolds have some advantages, however, they lack electrical activity which hinders their further use. In this study, a barium titanate (BaTiO3) piezoelectric ceramic was used to modify the surface of a porous Ti6Al4V scaffold (pTi), which was characterized by scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and roughness and water contact angle analyses. Low intensity pulsed ultrasound (LIPUS) was applied in vitro and in vivo study. The activity of bone marrow mesenchymal stem cells, including adhesion, proliferation, and gene expression, was significantly superior in the BaTiO3/pTi, pTi + LIPUS, and BaTiO3/pTi + LIPUS groups than in the pTi group. The activity was also higher in the BaTiO3/pTi + LIPUS group than in the BaTiO3/pTi and pTi + LIPUS groups. Additionally, micro-computed tomography, the mineral apposition rate, histomorphology, and the peak pull-out load showed that these scaffold conditions significantly enhanced osteogenesis and osseointegration 6 and 12 weeks after implantation in large segmental bone defects in the radius of rabbits compared with those resulting from the pTi condition. Consequently, the improved osteogenesis and osseointegration make the BaTiO3/pTi + LIPUS a promising method to promote bone regeneration in large segmental bone defects for clinical application.
KeywordLarge segmental bone defect Barium titanate Piezoelectric ceramic Porous Ti6Al4V scaffold Osteogenesis
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Development Program of Chinese People's Liberation Army
DOI10.1016/j.bioactmat.2020.07.001
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFC1104901] ; National Natural Science Foundation of China[51771227] ; National Natural Science Foundation of China[31800812] ; Youth Development Program of Chinese People's Liberation Army[20QNPY069]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000562478100030
PublisherKEAI PUBLISHING LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140308
Collection中国科学院金属研究所
Corresponding AuthorGuo, Zheng
Affiliation1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China
2.940 Hosp Joint Logist Support Force Chinese Peopl, Orthoped Ctr Spine Surg, Lanzhou 730050, Peoples R China
3.Hunan Normal Univ, Dept Joint Surg & Sports Med, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China
4.Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China
5.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Fan, Bo,Guo, Zheng,Li, Xiaokang,et al. Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects[J]. BIOACTIVE MATERIALS,2020,5(4):1087-1101.
APA Fan, Bo.,Guo, Zheng.,Li, Xiaokang.,Li, Songkai.,Gao, Peng.,...&Hou, Wentao.(2020).Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects.BIOACTIVE MATERIALS,5(4),1087-1101.
MLA Fan, Bo,et al."Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects".BIOACTIVE MATERIALS 5.4(2020):1087-1101.
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