Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects

doi:10.1016/j.bioactmat.2020.07.001

IMR OpenIR

	Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects
	Fan, Bo 1,2; Guo, Zheng 1; Li, Xiaokang 1; Li, Songkai 2; Gao, Peng 3,4; Xiao, Xin 1; Wu, Jie 1; Shen, Chao 1; Jiao, Yilai 5; Hou, Wentao 5
通讯作者	Guo, Zheng(guozheng@fmmu.edu.cn)
	2020-12-01
发表期刊	BIOACTIVE MATERIALS
卷号	5 期号:4 页码:1087-1101
摘要	For large segmental bone defects, porous titanium scaffolds have some advantages, however, they lack electrical activity which hinders their further use. In this study, a barium titanate (BaTiO3) piezoelectric ceramic was used to modify the surface of a porous Ti6Al4V scaffold (pTi), which was characterized by scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and roughness and water contact angle analyses. Low intensity pulsed ultrasound (LIPUS) was applied in vitro and in vivo study. The activity of bone marrow mesenchymal stem cells, including adhesion, proliferation, and gene expression, was significantly superior in the BaTiO3/pTi, pTi + LIPUS, and BaTiO3/pTi + LIPUS groups than in the pTi group. The activity was also higher in the BaTiO3/pTi + LIPUS group than in the BaTiO3/pTi and pTi + LIPUS groups. Additionally, micro-computed tomography, the mineral apposition rate, histomorphology, and the peak pull-out load showed that these scaffold conditions significantly enhanced osteogenesis and osseointegration 6 and 12 weeks after implantation in large segmental bone defects in the radius of rabbits compared with those resulting from the pTi condition. Consequently, the improved osteogenesis and osseointegration make the BaTiO3/pTi + LIPUS a promising method to promote bone regeneration in large segmental bone defects for clinical application.
关键词	Large segmental bone defect Barium titanate Piezoelectric ceramic Porous Ti6Al4V scaffold Osteogenesis
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Development Program of Chinese People's Liberation Army
DOI	10.1016/j.bioactmat.2020.07.001
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFC1104901] ; National Natural Science Foundation of China[51771227] ; National Natural Science Foundation of China[31800812] ; Youth Development Program of Chinese People's Liberation Army[20QNPY069]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000562478100030
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：118[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/140308
专题	中国科学院金属研究所
通讯作者	Guo, Zheng
作者单位	1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China 2.940 Hosp Joint Logist Support Force Chinese Peopl, Orthoped Ctr Spine Surg, Lanzhou 730050, Peoples R China 3.Hunan Normal Univ, Dept Joint Surg & Sports Med, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China 4.Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Fan, Bo,Guo, Zheng,Li, Xiaokang,et al. Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects[J]. BIOACTIVE MATERIALS,2020,5(4):1087-1101.
APA	Fan, Bo.,Guo, Zheng.,Li, Xiaokang.,Li, Songkai.,Gao, Peng.,...&Hou, Wentao.(2020).Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects.BIOACTIVE MATERIALS,5(4),1087-1101.
MLA	Fan, Bo,et al."Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects".BIOACTIVE MATERIALS 5.4(2020):1087-1101.