IMR OpenIR
An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics
Zhao, Xue1; Wan, Peng2; Wang, Hongyan1; Zhang, Shuwei1; Liu, Jingbo1; Chang, Chunrong1; Yang, Ke3; Pan, Yaping1,4
Corresponding AuthorYang, Ke(kyang@imr.ac.cn) ; Pan, Yaping(yppan@cmu.edu.cn)
2020-08-28
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Volume2020Pages:9
AbstractPeriodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth. In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties. In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, thein vitrodegradation and antibacterial performance were examined. The pH variation and Mg2+ and Cu2+ release of Mg-Cu alloy extracts were measured.Porphyromonas gingivalis(P. gingivalis) andAggregatibacter actinomycetemcomitans(A. actinomycetemcomitans), two common bacteria associated with periodontal disease, were cultured in Mg-Cu alloy extracts, and bacterial survival rate was evaluated. The changes of bacterial biofilm and its structure were revealed by scanning electron microscopy (SEM) and transmission electronic microscopy (TEM), respectively. The results showed that the Mg-Cu alloy could significantly decrease the survival rates of bothP. gingivalisandA. actinomycetemcomitans. Furthermore, the bacterial biofilms were completely destroyed in Mg-Cu alloy extracts, and the bacterial cell membranes were damaged, finally leading to bacterial apoptosis. These results indicate that the Mg-Cu alloy can effectively eliminate periodontal pathogens, and the use of Mg-Cu in periodontal bone grafts has a great potential to prevent infections after periodontal surgery.
Funding OrganizationTalents Plant for Liaoning Development ; Natural Science Foundation of China ; Research Start-Up Funds of DGUT
DOI10.1155/2020/7289208
Indexed BySCI
Language英语
Funding ProjectTalents Plant for Liaoning Development[XLYC1802129] ; Natural Science Foundation of China[51631009] ; Research Start-Up Funds of DGUT[GC300501-082]
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000570898700002
PublisherHINDAWI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140577
Collection中国科学院金属研究所
Corresponding AuthorYang, Ke; Pan, Yaping
Affiliation1.China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Liaoning, Peoples R China
2.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
4.China Med Univ, Sch & Hosp Stomatol, Dept Oral Biol, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Xue,Wan, Peng,Wang, Hongyan,et al. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020:9.
APA Zhao, Xue.,Wan, Peng.,Wang, Hongyan.,Zhang, Shuwei.,Liu, Jingbo.,...&Pan, Yaping.(2020).An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics.BIOMED RESEARCH INTERNATIONAL,2020,9.
MLA Zhao, Xue,et al."An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics".BIOMED RESEARCH INTERNATIONAL 2020(2020):9.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, Xue]'s Articles
[Wan, Peng]'s Articles
[Wang, Hongyan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, Xue]'s Articles
[Wan, Peng]'s Articles
[Wang, Hongyan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, Xue]'s Articles
[Wan, Peng]'s Articles
[Wang, Hongyan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.