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The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo
Gao, Ming1,2; Na, Di3; Ni, Xiangqiao3; Song, Lihui3; Etim, Iniobong P.1,2; Yang, Ke2; Tan, Lili2; Ma, Zheng2
Corresponding AuthorTan, Lili(lltan@imr.ac.cn) ; Ma, Zheng(zma@imr.ac.cn)
2021
Source PublicationBIOACTIVE MATERIALS
Volume6Issue:1Pages:55-63
AbstractTitanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach, however they cannot be absorbed in human body, which may cause a series of complications to influence further diagnosis. Magnesium and its alloy have great potential as surgical staples, because they can be degraded in human body and have good mechanical properties and biocompatibility. In this study, Mg-2Zn-0.5Nd (ZN20) alloy fine wires showed great potential as surgical staples. The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%, respectively, which could be benefit for the deformation of the surgical staples from U-shape to B-shape. The bursting pressure of the wire was about 40 kPa, implying that it can supply sufficient mechanical support after anastomosis. Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire. The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion. The second phase had a negative influence on corrosion property due to galvanic corrosion. The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.
KeywordMagnesium Surgical staple Anastomosis Corrosion resistance In vivo
Funding OrganizationKey Program of China on Biomedical Materials Research and Tissue Organ Replacement ; National Natural Science Foundation of China
DOI10.1016/j.bioactmat.2020.07.011
Indexed BySCI
Language英语
Funding ProjectKey Program of China on Biomedical Materials Research and Tissue Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue Organ Replacement[2016YFC1100604] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000574616100005
PublisherKEAI PUBLISHING LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140751
Collection中国科学院金属研究所
Corresponding AuthorTan, Lili; Ma, Zheng
Affiliation1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.China Med Univ, Dept Surg Oncol, Hosp 1, Shenyang, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Gao, Ming,Na, Di,Ni, Xiangqiao,et al. The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo[J]. BIOACTIVE MATERIALS,2021,6(1):55-63.
APA Gao, Ming.,Na, Di.,Ni, Xiangqiao.,Song, Lihui.,Etim, Iniobong P..,...&Ma, Zheng.(2021).The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo.BIOACTIVE MATERIALS,6(1),55-63.
MLA Gao, Ming,et al."The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo".BIOACTIVE MATERIALS 6.1(2021):55-63.
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