Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis

doi:10.1016/j.actbio.2020.09.005

IMR OpenIR

	Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis
	Yang, Hongwei 1; Yu, Meng 1,2; Wang, Rong 1; Li, Bo 1,2; Zhao, Xin 1; Hao, Yulin 3; Guo, Zheng 4; Han, Yong 1
通讯作者	Han, Yong(yonghan@mail.xjtu.edu.cn)
	2020-10-15
发表期刊	ACTA BIOMATERIALIA
ISSN	1742-7061
卷号	116 页码:400-414
摘要	Current bioactive modifications of Ti-based materials for promoting osteogenesis often decrease corrosion fatigue strength (sigma(cf)) of the resultant implants, thereby shortening their service lifespan. To solve this issue and accelerate the osteogenesis process, in the present study, a TiO 2 nanorods (TNR)-arrayed coating was hydrothermally grown on optimal surface mechanical attrition treated (SMATed) titanium (S-Ti). The microstructure, bond integrity, residual stress distribution, and corrosion fatigue of TNR-coated S-Ti (TNR/S-Ti) and the response of macrophages and bone marrow-derived mesenchymal stem cells (BMSCs) to TNR/S-Ti were investigated and compared with those of mechanically polished Ti (P-Ti), S-Ti, and TNR-coated P-Ti (TNR/P-Ti). S-Ti showed a nanograined layer and an underlying grain-deformed region with residual compressive stress, which was sustained even when it was hydrothermally coated with TNR. TNR on S-Ti showed nanotopography, composition, and bond strength almost identical to those of P-Ti. While TNR/P-Ti showed a considerable decrease in a ci , compared to P-Ti, TNR/S-Ti exhibited an improved sigma-cf which was even higher than that of P-Ti. Biologically, TNR/S-Ti enhanced adhesion, differentiation, and mineralization of BMSCs, and it also promoted adhesion and M1-to-M2 transition of macrophages as compared to S-Ti and P-Ti. With rapid phenotype switch of macrophages, the level of proinflammatory cytokines decreased, while anti-inflammatory cytokines were upregulated. In co-culture conditions, the migration, differentiation, and mineralization of BMSCs were enhanced by increased level of secretion factors of macrophages on TNR/S-Ti. The modified structure accelerated bone apposition in rabbit femur and is expected to induce a favorable immune microenvironment to facilitate osseointegration earlier; it can also simultaneously improve corrosion fatigue resistance of Ti-based implants and thereby enhance their service life. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
关键词	Surface mechanical attrition treatment TiO2 nanorods arrayed coating Corrosion fatigue Immunomodulation Osteogenesis
资助者	National Natural Science Foundation of China ; China Postdoctoral Science Foundation
DOI	10.1016/j.actbio.2020.09.005
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51631007] ; National Natural Science Foundation of China[51971171] ; National Natural Science Foundation of China[81901893] ; China Postdoctoral Science Foundation[2018M643631]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000577516000027
出版者	ELSEVIER SCI LTD
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/140948
专题	中国科学院金属研究所
通讯作者	Han, Yong
作者单位	1.Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China 2.Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Sch Life Sci & Technol, Xian 710049, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China
推荐引用方式 GB/T 7714	Yang, Hongwei,Yu, Meng,Wang, Rong,et al. Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis[J]. ACTA BIOMATERIALIA,2020,116:400-414.
APA	Yang, Hongwei.,Yu, Meng.,Wang, Rong.,Li, Bo.,Zhao, Xin.,...&Han, Yong.(2020).Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis.ACTA BIOMATERIALIA,116,400-414.
MLA	Yang, Hongwei,et al."Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis".ACTA BIOMATERIALIA 116(2020):400-414.