IMR OpenIR
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions
Zeng, Guoming1,2; Jin, Libo3,4,5; Ying, Qinsi6; Chen, Haojie3; Thembinkosi, Murinda Charmaine3; Yang, Chunguang7; Zhao, Jinlong7; Ji, Hao3; Lin, Sue3; Peng, Renyi3; Zhang, Maolan1,3; Sun, Da3
Corresponding AuthorZhang, Maolan(zml@cqu.edu.cn) ; Sun, Da(sunday@wzu.edu.cn)
2020
Source PublicationCANCER MANAGEMENT AND RESEARCH
ISSN1179-1322
Volume12Pages:10411-10421
AbstractCancer immunotherapy is a promising approach that has recently gained its importance in treating cancer. Despite various approaches of immunotherapies being used to target cancer cells, they are either not effective against all types of cancer or for all patients. Although efforts are being made to improve the cancer immunotherapy in all possible ways, one important hindrance that lowers the immune response to kill cancer cells is the infiltration of Regulatory T (Treg) cells into the tumor cells, favoring tumor progression, on one hand, and inhibiting the activation of T cells to respond to cancer cells, on the other hand. Therefore, new anti-cancer drugs and vaccines fail to show promising results against cancer. This is due to the infiltration of Treg cells into the tumor region and suppression of anti-cancer activity. Thus, regardless of various types of immunotherapies being practiced, understanding the mechanisms of how Treg cells favor tumor progression and inhibition of anti-cancer activity is worthwhile. Therefore, the review highlights the importance of Tregs cells and how depletion of Treg cells can pave the way to an effective immunotherapy by activating the immune responses against cancer.
Keywordcancer immunotherapy Treg cells FoxP3 targeting Treg cells anti-cancer
Funding OrganizationNatural Science Foundation of Zhejiang Province ; National Natural Science Foundation of China ; Shenzhen Science and Technology Research Funding ; Special project of basic research and frontier exploration in Chongqing
DOI10.2147/CMAR.S265828
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Zhejiang Province[Q19E010021] ; Natural Science Foundation of Zhejiang Province[LQ20C020003] ; Natural Science Foundation of Zhejiang Province[LQ20C200015] ; National Natural Science Foundation of China[51901160] ; National Natural Science Foundation of China[51808086] ; Shenzhen Science and Technology Research Funding[JCYJ20160608153641020] ; Special project of basic research and frontier exploration in Chongqing[cstc2018jcyjAX0078]
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000579720000004
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/140957
Collection中国科学院金属研究所
Corresponding AuthorZhang, Maolan; Sun, Da
Affiliation1.Chongqing Univ Sci & Technol, Chongqing 401331, Peoples R China
2.China Met Construct Engn Grp Co Ltd, Chongqing 400044, Peoples R China
3.Wenzhou Univ, Inst Life Sci, Higher Educ Pk, Wenzhou 325035, Zhejiang, Peoples R China
4.Biomed Collaborat Innovat Ctr Zhejiang Prov, Wenzhou 325035, Zhejiang, Peoples R China
5.Biomed Collaborat Innovat Ctr Wenzhou, Engn Lab Zhejiang Prov Pharmaceut Dev Growth Fact, Wenzhou 325035, Zhejiang, Peoples R China
6.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325035, Zhejiang, Peoples R China
7.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Guoming,Jin, Libo,Ying, Qinsi,et al. Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions[J]. CANCER MANAGEMENT AND RESEARCH,2020,12:10411-10421.
APA Zeng, Guoming.,Jin, Libo.,Ying, Qinsi.,Chen, Haojie.,Thembinkosi, Murinda Charmaine.,...&Sun, Da.(2020).Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions.CANCER MANAGEMENT AND RESEARCH,12,10411-10421.
MLA Zeng, Guoming,et al."Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions".CANCER MANAGEMENT AND RESEARCH 12(2020):10411-10421.
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