| Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis | |
| Luo, J. P.1,2,3; Huang, Y. J.3; Xu, J. Y.1,2,4; Sun, J. F.3; Dargusch, M. S.4; Hou, C. H.5; Ren, L.6; Wang, R. Z.7; Ebel, T.8; Yan, M.1,2 | |
| Corresponding Author | Sun, J. F.(jfsun@hit.edu.cn) ; Yan, M.(yanm@sustech.edu.cn) |
| 2020-09-01 | |
| Source Publication | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| ISSN | 0928-4931 |
| Volume | 114Pages:16 |
| Abstract | Some beta-Ti alloys, such as Ti-Nb-Ta-Zr (TNTZ) alloys, exhibit a low Young's modulus and excellent biocompatibility. These alloys are promising new generation biomedical implant materials. Selective laser melting (SLM) can further enable customer-specific manufacturing of beta-Ti alloys to satisfy the ever-increasing need for enhanced biomedical products. In this study, we quantitatively determined the relationships between porosity, yield strength, and Young's modulus of SLM-prepared TNTZ lattices. The study constitutes a critical step toward understanding the behavior of the lattice and eventually enables tuning the Young's modulus to match that of human bones. Fatigue properties were also investigated on as-printed lattices in terms of the stress limit. The biocompatibility study included a routine evaluation of the relative cell growth rate and a proteomics analysis using a common mouse fibroblast cell line, L929. The results indicated that the as-printed TNTZ samples exhibited evidence of protein proliferation of the L929 cells, particularly P06733, and that those proteins are responsible for biological processes and molecular functions. They in turn may have promoted cell regeneration, cell motility, and protein binding, which at least partially explains the good biocompatibility of the as-printed TNTZ at the protein level. The study highlights the promising applications of additively manufactured TNTZ as a bone-replacing material from mechanical and biocompatibility perspectives. |
| Keyword | Selective laser melting Ti-Nb-Ta-Zr (TNTZ) Mechanical properties Biocompatibility Proteomics |
| Funding Organization | Science, Technology and Innovation Commission of Shenzhen Municipality ; Science Foundation of Guangdong Province ; Humboldt Foundation Research Fellowship for Experienced Researchers ; Pico Center at SUSTech ; Presidential Fund and Development and Reform Commission of Shenzhen Municipality ; Australian Research Council through the ARC Research Hub for Advanced Manufacturing of Medical Devices |
| DOI | 10.1016/j.msec.2020.110903 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Science, Technology and Innovation Commission of Shenzhen Municipality[ZDSYS201703031748354] ; Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20150529152146478] ; Science Foundation of Guangdong Province[2016A030313756] ; Humboldt Foundation Research Fellowship for Experienced Researchers ; Pico Center at SUSTech ; Presidential Fund and Development and Reform Commission of Shenzhen Municipality ; Australian Research Council through the ARC Research Hub for Advanced Manufacturing of Medical Devices[IH1501000024] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| WOS ID | WOS:000579654700011 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/141043 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Sun, J. F.; Yan, M. |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Key Lab Addit Mfg High Performance Mat, Shenzhen 518055, Peoples R China 3.Harbin Inst Technol, Sch Mat Sci & Engn, Harbin 150001, Peoples R China 4.Univ Queensland, Sch Mech & Min Engn, Brisbane, Qld 4072, Australia 5.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China 6.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 7.Univ British Columbia, Dept Mat Engn, Vancouver, BC V6T 1Z4, Canada 8.Helmholtz Zentrum Geesthacht, Inst Mat Res, D-21502 Geesthacht, Germany |
| Recommended Citation GB/T 7714 | Luo, J. P.,Huang, Y. J.,Xu, J. Y.,et al. Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,114:16. |
| APA | Luo, J. P..,Huang, Y. J..,Xu, J. Y..,Sun, J. F..,Dargusch, M. S..,...&Yan, M..(2020).Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,114,16. |
| MLA | Luo, J. P.,et al."Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 114(2020):16. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment