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Multicenter clinical study for evaluation of efficacy and safety of transdermal fentanyl matrix patch in treatment of moderate to severe cancer pain in 474 Chinese cancer patients
Alternative TitleMulticenter Clinical Study for Evaluation of Efficacy and Safety of Transdermal Fentanyl Matrix Patch in Treatment of Moderate to Severe Cancer Pain in 474 Chinese Cancer Patients
Zhu Yulin1; Song Guohong1; Liu Duanqi2; Zhang Xi3; Liu Kuifeng4; Zang Aihua5; Cheng Ying5; Cao Guochun5; Liang Jun6; Ma Xuezhen7; Ding Xin8; Wang Bin9; Li Weilian10; Hu Zuowei11; Feng Gang12; Huang Jiangjin13; Zheng Xiao5; Jiao Shunchang14; Wu Rong15; Ren Jun1
2011
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume23Issue:4Pages:317-322
AbstractAlthough a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain.
Other AbstractObjective Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 μg Results After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63±1.26 to 2.03±1.46 ( P <0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment ( P <0.0001). Conclusion The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.
KeywordAVAILABLE RESERVOIR FORMULATION LONG-TERM TREATMENT QUALITY-OF-LIFE PHARMACOLOGICAL-PROPERTIES THERAPEUTIC-EFFICACY DELIVERY-SYSTEM ORAL MORPHINE OPIOIDS TRIAL PHARMACOKINETICS Transdermal fentanyl matrix patch (TDF) Cancer pain Efficacy Safety Quality of life
Indexed ByCSCD
Language英语
CSCD IDCSCD:4406493
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/141548
Collection中国科学院金属研究所
Affiliation1.北京大学
2.PLA Mil Gen Hosp Beijing, Beijing 100009, Peoples R China
3.3 Peoples Hosp Chengdu, Chengdu 610031, Peoples R China
4.中国科学院广州地球化学研究所
5.中国科学院合肥物质科学研究院肿瘤医院
6.青岛大学
7.黑龙江省环境保护科学研究院
8.Shanghai Huaihai Hosp, Shanghai 200031, Peoples R China
9.Suzhou Municipal Hosp, Suzhou 215001, Peoples R China
10.Tianjin Peoples Hosp, Tianjin 300121, Peoples R China
11.Wuhan Integrated TCM & Western Med Hosp, Wuhan 430070, Peoples R China
12.Pu Ai Hosp Wuhan City, Wuhan 430070, Peoples R China
13.浙江大学
14.Gen Hosp Peoples Liberat Army, Beijing 100853, Peoples R China
15.中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhu Yulin,Song Guohong,Liu Duanqi,et al. Multicenter clinical study for evaluation of efficacy and safety of transdermal fentanyl matrix patch in treatment of moderate to severe cancer pain in 474 Chinese cancer patients[J]. CHINESE JOURNAL OF CANCER RESEARCH,2011,23(4):317-322.
APA Zhu Yulin.,Song Guohong.,Liu Duanqi.,Zhang Xi.,Liu Kuifeng.,...&Ren Jun.(2011).Multicenter clinical study for evaluation of efficacy and safety of transdermal fentanyl matrix patch in treatment of moderate to severe cancer pain in 474 Chinese cancer patients.CHINESE JOURNAL OF CANCER RESEARCH,23(4),317-322.
MLA Zhu Yulin,et al."Multicenter clinical study for evaluation of efficacy and safety of transdermal fentanyl matrix patch in treatment of moderate to severe cancer pain in 474 Chinese cancer patients".CHINESE JOURNAL OF CANCER RESEARCH 23.4(2011):317-322.
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