Promoter hypermethylation of KiSS-1 gene in gastric cancer

IMR OpenIR

	Promoter hypermethylation of KiSS-1 gene in gastric cancer
其他题名	Promoter Hypermethylation of KiSS-1 Gene in Gastric Cancer
	Yang Zhi; Dai DongQiu; Du YunYi
	2010
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	22 期号:4 页码:280-284
摘要	To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases.
其他摘要	Objective:To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritoneal lavage fluid in detecting peritoneal metastases. Methods:The methylation status of KiSS-1 gene in 40 gastric cancer specimens,the corresponding adjacent normal mucosa,lymph nodes and peritoneal lavage fluid was investigated by methylation-spcific polymerase chain reaction(MS-PCR). Results:Aberrant methylation of KiSS-1 gene was detected in 55%(22/40)of the adjacent normal mucosa,82.5%(33/40)of gastric cancer specimens,80.95%(17/21)of the lymph nodes,and 42.5%(17/40) of peritoneal lavage fluid.Methylation in gastric carcinoma and lymphonode was more frequent than in non-neoplastic gastiric mucosa.Presence of KiSS-1 methylation in peritoneal lavage fluid was significantly correlated with tumor invasion(P=0.043).The accuracy of KiSS-1 methylation in peritoneal lavage fluid for diagnosing peritoneal metastasis was 70%,with a sensitivity of 77.8%and a specificity of 67.7%. Conclusion:Aberrant methylation of KiSS-1 gene is a common event in the occurrence and progression of gastric carcinoma,which may provide useful information for the early diagnosis of peritoneal metastases and a new therapy for gastric cancer
关键词	LUNG-CANCER PERITONEAL-LAVAGE COLORECTAL-CANCER MULTIPLE GENES BREAST-CANCER TUMOR-CELLS METHYLATION DNA EXPRESSION CARCINOMA Gastric cancer Methylation KiSS-1 Peritoneal lavage fluid
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Science Foundation for High Education]
CSCD记录号	CSCD:4075598
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/141845
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Yang Zhi,Dai DongQiu,Du YunYi. Promoter hypermethylation of KiSS-1 gene in gastric cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(4):280-284.
APA	Yang Zhi,Dai DongQiu,&Du YunYi.(2010).Promoter hypermethylation of KiSS-1 gene in gastric cancer.CHINESE JOURNAL OF CANCER RESEARCH,22(4),280-284.
MLA	Yang Zhi,et al."Promoter hypermethylation of KiSS-1 gene in gastric cancer".CHINESE JOURNAL OF CANCER RESEARCH 22.4(2010):280-284.