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Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis
Alternative TitleCyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis
Liu JiaLi1; Liang Yuan2; Wang ZhenNing1; Zhou Xin1; Xing LiLi2
2010
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume16Issue:43Pages:5510-5517
AbstractAIM: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.
Other AbstractAIM: To investigate the association of the cyclooxygenases-2(COX-2)polymorphisms and susceptibility to gastric cancer(GC)by means of meta-analysis. METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE,EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR)with 95%confidence interval(CI)was calculated. RESULTS: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C,-1195A, -1290G,*2430T alleles and*429TT genotype revealed increased risk for GC(OR=1.71,95%CI:1.01-2.90,P =0.05;OR=1.58,95%CI:1.05-2.38,P=0.03;OR= 1.55,95%CI:1.01-2.39,P=0.05;OR=2.62,95%CI: 1.20-5.73,P=0.02 and OR=0.74,95%CI:0.59-0.95, P=0.02, respectively). CONCLUSION: The-765C,-1195A,-1290G,*2430T alleles and*429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC
KeywordGASTROINTESTINAL-TRACT CANCER EXPRESSION ADENOCARCINOMA COX-2 CARCINOGENESIS EPIDEMIOLOGY ANGIOGENESIS INFLAMMATION RISK Cyclooxygenases-2 Gastric cancer Polymorphisms Susceptibility Meta-analysis
Indexed ByCSCD
Language英语
Funding Project[National Science Foundation of China] ; [Education Department of Liaoning Province]
CSCD IDCSCD:4051416
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142219
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.中国科学院南海海洋研究所
Recommended Citation
GB/T 7714
Liu JiaLi,Liang Yuan,Wang ZhenNing,et al. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(43):5510-5517.
APA Liu JiaLi,Liang Yuan,Wang ZhenNing,Zhou Xin,&Xing LiLi.(2010).Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis.WORLD JOURNAL OF GASTROENTEROLOGY,16(43),5510-5517.
MLA Liu JiaLi,et al."Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis".WORLD JOURNAL OF GASTROENTEROLOGY 16.43(2010):5510-5517.
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