| Melatonin lowers edema after spinal cord injury | |
| Alternative Title | Melatonin lowers edema after spinal cord injury |
| Li Cheng1; Chen Xiao1; Qiaol Suchi1; Liu Xinwei2; Liu Chang1; Zhu Degang1; Su Jiacan1; Wang Zhiwei1 | |
| 2014 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 9Issue:24Pages:2205-2210 |
| Abstract | Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein. |
| Other Abstract | Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg |
| Keyword | RANDOMIZED CONTROLLED-TRIAL AQUAPORIN-4 EXPRESSION TIRILAZAD MESYLATE SECONDARY INJURY ISCHEMIC-INJURY NEURONAL DEATH WATER CHANNELS BRAIN EDEMA METHYLPREDNISOLONE RATS nerve regeneration spinal cord injury melatonin edema aquaporin glial fibrillary acidic protein immunohistochemistry western blot assay neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [China Postdoctoral Science Foundation Grant] |
| CSCD ID | CSCD:5325093 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142271 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Second Mil Med University, Changhai Hosp, Dept Orthoped Surg, Shanghai 200433, Peoples R China 2.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Li Cheng,Chen Xiao,Qiaol Suchi,et al. Melatonin lowers edema after spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2205-2210. |
| APA | Li Cheng.,Chen Xiao.,Qiaol Suchi.,Liu Xinwei.,Liu Chang.,...&Wang Zhiwei.(2014).Melatonin lowers edema after spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2205-2210. |
| MLA | Li Cheng,et al."Melatonin lowers edema after spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2205-2210. |
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