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Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors
Alternative TitleSyntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors
Liu Yan1; Zhong Wu1; Li Song1
2012
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume23Issue:2Pages:133-136
AbstractA short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)benzoic acid derivatives (8a-g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and H-1 NMR. (C) 2011 Wu Zhong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA short and efficient synthesis of(Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)ben-zoic acid derivatives(8a-g) as potential type of FabH inhibitors is described.Their structures were confirmed by MS,NOE and ~1H NMR.
KeywordFATTY-ACID SYNTHASE TUBERCULOSIS CLONING Tuberculosis Mycobacterium tuberculosis FabH Enzyme inhibitor Synthesis NOE
Indexed ByCSCD
Language英语
Funding Project[National High Technology Research and Development Program of China]
CSCD IDCSCD:4448329
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142379
Collection中国科学院金属研究所
Affiliation1.Beijing Institute Pharmacol & Toxicol, Lab Comp Aided Drug Design & Discovery, Beijing 100850, Peoples R China
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Liu Yan,Zhong Wu,Li Song. Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors[J]. CHINESE CHEMICAL LETTERS,2012,23(2):133-136.
APA Liu Yan,Zhong Wu,&Li Song.(2012).Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors.CHINESE CHEMICAL LETTERS,23(2),133-136.
MLA Liu Yan,et al."Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors".CHINESE CHEMICAL LETTERS 23.2(2012):133-136.
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