IMR OpenIR
Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis
Alternative TitleIncreased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis
Guo Yingying; Wang Naizhi; Zhao Shuai; Hou Linxin; Xu Yanbing; Zhang Ning
2013
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume126Issue:5Pages:850-854
AbstractBackground Interleukin-23 (IL-23) is a pro-inflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not the serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA), and to determine the relationship between the IL-23 level and disease activity in RA patients.
Other AbstractBackground Interleukin-23 (IL-23) is a pro-inflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not the serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA), and to determine the relationship between the IL-23 level and disease activity in RA patients. Methods Serum samples were obtained from 59 patients with RA and 30 healthy controls. The clinical parameters of disease activity were determined, including the 28-joint disease activity score (DAS28), C-reactive protein (CRP), rheumatoid factor (RF) levels, and the degree of bony erosions based on X-rays. The levels of IL-23 and IL-17 were determined by enzyme-linked immunosorbent assay (ELISA). The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined. Results The serum IL-23 level was significantly elevated in patients with RA compared to healthy controls. The serum IL-23 levels in the RA patients correlated with IL-17 and CRP levels, and the DAS28. The levels of IL-23 based on X-ray classification phase I, II, III, and IV were gradually elevated in RA patients. Conclusions The levels of serum IL-23 in RA patients were higher than in healthy controls. Thus, elevated serum IL-23 levels may be useful markers to detect active RA. In addition, IL-23 is involved in disease progression and bony erosions in patients with RA.
KeywordT-CELL-ACTIVATION AUTOIMMUNE INFLAMMATION IL-23 CYTOKINE RECEPTOR BONE TH17 PATHOGENESIS PROMOTES DISTINCT rheumatoid arthritis interleukin-23 interleukin-17 C-reactive protein
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4767764
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142425
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Guo Yingying,Wang Naizhi,Zhao Shuai,et al. Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis[J]. CHINESE MEDICAL JOURNAL,2013,126(5):850-854.
APA Guo Yingying,Wang Naizhi,Zhao Shuai,Hou Linxin,Xu Yanbing,&Zhang Ning.(2013).Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis.CHINESE MEDICAL JOURNAL,126(5),850-854.
MLA Guo Yingying,et al."Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis".CHINESE MEDICAL JOURNAL 126.5(2013):850-854.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo Yingying]'s Articles
[Wang Naizhi]'s Articles
[Zhao Shuai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo Yingying]'s Articles
[Wang Naizhi]'s Articles
[Zhao Shuai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo Yingying]'s Articles
[Wang Naizhi]'s Articles
[Zhao Shuai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.