Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis

IMR OpenIR

	Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis
其他题名	Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis
	Guo Yingying; Wang Naizhi; Zhao Shuai; Hou Linxin; Xu Yanbing; Zhang Ning
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	126 期号:5 页码:850-854
摘要	Background Interleukin-23 (IL-23) is a pro-inflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not the serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA), and to determine the relationship between the IL-23 level and disease activity in RA patients.
其他摘要	Background Interleukin-23 (IL-23) is a pro-inflammatory cytokine that is thought to be central to the development of autoimmune diseases. This study was conducted to determine whether or not the serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA), and to determine the relationship between the IL-23 level and disease activity in RA patients. Methods Serum samples were obtained from 59 patients with RA and 30 healthy controls. The clinical parameters of disease activity were determined, including the 28-joint disease activity score (DAS28), C-reactive protein (CRP), rheumatoid factor (RF) levels, and the degree of bony erosions based on X-rays. The levels of IL-23 and IL-17 were determined by enzyme-linked immunosorbent assay (ELISA). The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined. Results The serum IL-23 level was significantly elevated in patients with RA compared to healthy controls. The serum IL-23 levels in the RA patients correlated with IL-17 and CRP levels, and the DAS28. The levels of IL-23 based on X-ray classification phase I, II, III, and IV were gradually elevated in RA patients. Conclusions The levels of serum IL-23 in RA patients were higher than in healthy controls. Thus, elevated serum IL-23 levels may be useful markers to detect active RA. In addition, IL-23 is involved in disease progression and bony erosions in patients with RA.
关键词	T-CELL-ACTIVATION AUTOIMMUNE INFLAMMATION IL-23 CYTOKINE RECEPTOR BONE TH17 PATHOGENESIS PROMOTES DISTINCT rheumatoid arthritis interleukin-23 interleukin-17 C-reactive protein
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4767764
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142425
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Guo Yingying,Wang Naizhi,Zhao Shuai,et al. Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis[J]. CHINESE MEDICAL JOURNAL,2013,126(5):850-854.
APA	Guo Yingying,Wang Naizhi,Zhao Shuai,Hou Linxin,Xu Yanbing,&Zhang Ning.(2013).Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis.CHINESE MEDICAL JOURNAL,126(5),850-854.
MLA	Guo Yingying,et al."Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis".CHINESE MEDICAL JOURNAL 126.5(2013):850-854.