| Risk analysis of hepatocellular carcinoma in Northeast China | |
| Alternative Title | Risk Analysis of Hepatocellular Carcinoma in Northeast China |
| Jia Zhifang1; Su Meng2; He Miao1; Yin Zhihua1; Wu Wei1; Li Xuelian1; Guan Peng1; Zhou Baosen1 | |
| 2009 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 21Issue:4Pages:304-309 |
| Abstract | It is known that chronic hepatitis B virus (HBV) infection is a main risk factor for hepatocellular carcinoma (HCC). To assess the effect of HBV infection and its interaction with other factors on the risk for HCC, a hospital-based case-control study was carried out in Northeast China. |
| Other Abstract | Objective: It is known that chronic hepatitis B virus (HBV) infection is a main risk factor for hepatocellular carcinoma (HCC). To assess the effect of HBV infection and its interaction with other factors on the risk for HCC, a hospital-based case-control study was carried out in Northeast China. Methods: A total of 384 cases with hepatocellular carcinoma and 432 controls without evidence of liver diseases were enrolled in the study. Blood samples were collected to detect the serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and questionnaires about lifestyle and family tumor history were performed in all subjects. Results: The total infection rate of HBV in hepatocellular carcinoma cases was 70.8% and 10.0% in non-liver disease controls. There was a statistically significant difference (P<0.0001) between cases and controls (OR= 22.0; 95%CI:15.0-32.3). Interaction analysis indicated that in HBV chronic carriers with HCV infection or alcohol consumption or family HCC history, the risk for HCC increased (OR=41.1, 95%CI: 20.2-83.9, OR=125.0, 95%CI: 66.5-235.2; OR=56.9, 95%CI: 27.2-119.3 respectively). In addition, hepatitis B history, HCV infection, hepatic cirrhosis and family history of HCC were also potential HCC independent risk factors. Conclusion: We confirmed that HBV is a chief risk factor for hepatocellular carcinoma and accounts for 67.7% of all hepatocellular carcinoma in Northeast China. HCV infection, alcohol intake and family history could enhance the risk for HCC in chronic HBV carriers. |
| Keyword | HEPATITIS-B Hepatitis B virus Hepatocellular carcinoma Risk factors |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Department of Education of Laoning Provincial] |
| CSCD ID | CSCD:3756732 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142503 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院合肥物质科学研究院肿瘤医院 |
| Recommended Citation GB/T 7714 | Jia Zhifang,Su Meng,He Miao,et al. Risk analysis of hepatocellular carcinoma in Northeast China[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):304-309. |
| APA | Jia Zhifang.,Su Meng.,He Miao.,Yin Zhihua.,Wu Wei.,...&Zhou Baosen.(2009).Risk analysis of hepatocellular carcinoma in Northeast China.CHINESE JOURNAL OF CANCER RESEARCH,21(4),304-309. |
| MLA | Jia Zhifang,et al."Risk analysis of hepatocellular carcinoma in Northeast China".CHINESE JOURNAL OF CANCER RESEARCH 21.4(2009):304-309. |
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