| Cytotoxin-associated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review | |
| Alternative Title | Cytotoxin-associated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review |
| Zhang Shuo; Guo Yang; Ma Yan; Teng Yue | |
| 2008 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 121Issue:10Pages:946-951 |
| Abstract | Objective A systematic meta-analysis was performed to explore the role of cytotoxin-associated gene-A (CagA) seropositive strains of Helicobacter pylori (H. pylon) in the pathogenesis of atherosclerotic diseases. |
| Other Abstract | Objective A systematic meta-analysis was performed to explore the role of cytotoxin-associated gene-A (CagA)seropositive strains of Helicobacterpylori (H. pylon) in the pathogenesis of atherosclerotic diseases.Data sources Data from Medline, EMBASE, CBMdisc, CNKI and the Cochrane Collaboration database were searched.Similar search strategies were applied to each of these databases.Study selection The review was restricted to the case-control studies on infective, chronic virulent CagA strains of H.pylori, involving the risk of ischemic stroke and coronary heart disease, ineligible studies were excluded. Two reviewers independently extracted the data and assessed study quality.Results Totally 26 case-control studies (11 studies on ischemic stroke and 15 studies on coronary heart disease) were retrieved and considered. The combined data revealed that the chronic seropositive virulent strains of H. pylori infection had a trend of increasing the risk of ischemic strokes and coronary heart diseases, yielding pooled Ors of 2.68 (95% CI: 2.20, 3.27)and 2.11 (95% CI: 1.70, 2.62), respectively. We also performed subgroup analyses, dividing the total population into Caucasian and Chinese subgroups. Through the subgroup analysis, no significant difference was found between the subgroups.Conclusions Our results support the hypothesis that CagA-seropositive strains infection is significantly associated with susceptibility to ischemic strokes and coronary heart diseases. The magnitude of the association with atherosclerotic diseases needs to be confirmed by prospective studies and the studies on CagA-seropositive strains eradication are more important. |
| Keyword | ISCHEMIC-HEART-DISEASE MYOCARDIAL-INFARCTION INFECTION CAGA INFLAMMATION STROKE RISK LINK PREVALENCE ANTIBODIES cytotoxin-associated gene-A ischemic stroke coronary heart diseases systematic review |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3383547 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142549 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhang Shuo,Guo Yang,Ma Yan,et al. Cytotoxin-associated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review[J]. CHINESE MEDICAL JOURNAL,2008,121(10):946-951. |
| APA | Zhang Shuo,Guo Yang,Ma Yan,&Teng Yue.(2008).Cytotoxin-associated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review.CHINESE MEDICAL JOURNAL,121(10),946-951. |
| MLA | Zhang Shuo,et al."Cytotoxin-associated gene-A-seropositive virulent strains of Helicobacter pylori and atherosclerotic diseases: a systematic review".CHINESE MEDICAL JOURNAL 121.10(2008):946-951. |
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