Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia

IMR OpenIR

	Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
其他题名	Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
	Xu Wangshu 1; Sun Xuan 3; Song Chengguang 1; Mu Xiaopeng 1; Ma Wenping 5; Zhang Xinghu 2; Zhao Chuansheng 1
	2016
发表期刊	Neural Regeneration Research
ISSN	1673-5374
卷号	11 期号:5 页码:745-751
摘要	Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia. We established a rat model of cerebral ischemia by injecting endothelin-1 in the left cortical motor area and left corpus striatum. Seven days later, bumetanide 200 μg/kg/day was injected into the lateral ventricle for 21 consecutive days with a mini-osmotic pump. Results demonstrated that the number of neuroblasts cells and the total length of dendrites increased, escape latency reduced, and the number of platform crossings increased in the rat hippocampal dentate gyrus in the chronic stage of cerebral ischemia. These findings suggest that bumetanide promoted neural precursor cell regeneration, dendritic development and the recovery of cognitive function, and protected brain tissue in the chronic stage of ischemia.
关键词	nerve regeneration Neurology. Diseases of the nervous system RC346-429 cerebral ischemia bumetanide Na + -K + -2Cl- cotransporter 1 hippocampal dentate gyrus neurogenesis neural precursor cells dendritic development cognitive function neural regeneration
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5715079
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/142876
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Capital Med University, Beijing Tiantan Hosp, Dept Neurol, Neuroinfect & Neuroimmunol Ctr, Beijing, Peoples R China 3.Capital Med University, Beijing Tiantan Hosp, Dept Intervent Neuroradiol, Beijing, Peoples R China 4.China Med University, Benxi Cent Hosp, Dept Neurol, Benxi, Liaoning Provin, Peoples R China 5.北京大学
推荐引用方式 GB/T 7714	Xu Wangshu,Sun Xuan,Song Chengguang,et al. Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia[J]. Neural Regeneration Research,2016,11(5):745-751.
APA	Xu Wangshu.,Sun Xuan.,Song Chengguang.,Mu Xiaopeng.,Ma Wenping.,...&Zhao Chuansheng.(2016).Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia.Neural Regeneration Research,11(5),745-751.
MLA	Xu Wangshu,et al."Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia".Neural Regeneration Research 11.5(2016):745-751.