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A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy
Alternative TitleA prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy
Hua Wei1; Wang Dongmei1; Cai Lin1; Sun Chaofeng1; Fu Guosheng1; Wang Yutang1; Yan Ji1; Luo Zhiling1; Xu Jing1; Wang Zhiyong1; Xu Geng1; Shen Farong1; Xu Wei1; Wang Jingfeng1; Ren Xuejun1; Jin Wei1; Zhang Nan1; Lau Elizabeth OiYan1; Zhang Shu1
2012
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume125Issue:3Pages:428-433
AbstractBackground Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt (TM), in Chinese patients treated with CRT.
Other AbstractBackground Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt~(TM), in Chinese patients treated with CRT. Methods Aortic time velocity integrals (AVTI) achieved at the sensed atrioventricular (AV), paced AV and interventricular (VV) interval settings recommended by both QuickOpt~(TM) and standard echocardiographic optimization were measured in 101 patients. Consistency and the strength of the relationship between the two timing cycle optimization methods were assessed by intra-class correlation coefficient (ICC). Results The ICC showed good agreement and correlation with what the AVTI achieved at the optimal sensed AV (ICC=0.9683 (0.9535–0.9785)), paced AV (ICC=0.9642 (0.9475–0.9757)) and VV (ICC=0.9730 (0.9602–0.9817)) interval settings determined by the two optimization methods. The average time required by echocardiographic optimization and by QuickOpt~(TM) were (78.32±32.40) minutes and (1.98±1.64) minutes respectively (P <0.0001). Conclusion The QuickOpt~(TM) algorithm provides a quicker, simpler and reliable alternative to the standard method for timing cycle optimization. (ClinicalTrial.gov Reference Number: NCT00918294)
KeywordSEVERE HEART-FAILURE DELAY OPTIMIZATION CONDUCTION DELAY VV-DELAY ECHO ECHOCARDIOGRAPHY TRIAL heart failure cardiac resynchronization therapy atrioventricular interval interventricular interval timing cycle optimization echocardiography aortic velocity time integral intracardiac electrogram QuickOpt (TM)
Indexed ByCSCD
Language英语
Funding Project[St. Jude Medical Inc.] ; [China Health & Medical Development Foundation]
CSCD IDCSCD:4432881
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142930
Collection中国科学院金属研究所
Affiliation1.Peking Union Med Coll
2.Chinese Acad Med Sci Dept Cardiol Cardiovasc Institute
3.中国医学科学院
4.中国科学院金属研究所
5.Chongqing Med University
6.Xi An Jiao Tong University
7.浙江大学
8.中国人民解放军总医院
9.Anhui Prov Hosp
10.Kunming Med Coll
11.Tianjin Chest Hosp
12.Inner Mongolian Peoples Hosp
13.Zhejiang Hosp
14.南京大学
15.Sun Yat Sen University
16.Capital Med University
17.上海交通大学
Recommended Citation
GB/T 7714
Hua Wei,Wang Dongmei,Cai Lin,et al. A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy[J]. CHINESE MEDICAL JOURNAL,2012,125(3):428-433.
APA Hua Wei.,Wang Dongmei.,Cai Lin.,Sun Chaofeng.,Fu Guosheng.,...&Zhang Shu.(2012).A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy.CHINESE MEDICAL JOURNAL,125(3),428-433.
MLA Hua Wei,et al."A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy".CHINESE MEDICAL JOURNAL 125.3(2012):428-433.
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