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Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2
Alternative TitleEremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2
Huang Yong Fu1; Qiao Li2; Lv A Li2; Pei Yue Hu2; Tian Li3
2008
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume19Issue:5Pages:562-564
AbstractSix eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 (11)-dien-7 alpha-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydroxypetasol (4), 8 alpha-hydroxy-13-deo -xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a new compound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388, A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide rings in eremophilane molecules were essential for their activity, and acetylation could enhance their activity. (C) 2008 Yong Fu Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractSix eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidatedas 3-acetyl-9, 7 (11)-dien-7ot-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydro-xypetasol (4), 8α-hydroxy-13-deo -xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a newcompound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388,A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide tings in eremophilanemolecules were essential for their activity, and acetylation could enhance their activity.2008 Yong Fu Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Keywordmarine fungus eremophilane sesquiterpenes NMR analysis cytotoxic activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3316730
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/142967
Collection中国科学院金属研究所
Affiliation1.China Agr Univ, Coll Agron & Biotechnology, Dept Plant Pathol, Beijing 100094, Peoples R China
2.中国科学院金属研究所
3.青岛大学
Recommended Citation
GB/T 7714
Huang Yong Fu,Qiao Li,Lv A Li,et al. Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2[J]. CHINESE CHEMICAL LETTERS,2008,19(5):562-564.
APA Huang Yong Fu,Qiao Li,Lv A Li,Pei Yue Hu,&Tian Li.(2008).Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2.CHINESE CHEMICAL LETTERS,19(5),562-564.
MLA Huang Yong Fu,et al."Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2".CHINESE CHEMICAL LETTERS 19.5(2008):562-564.
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