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LaF3:Tb Nanoparticles Coated with 5-Aminoisophthalic Acid Sensitizer and Their Applications in Immunolabeling and Imaging of Hela Cells
Alternative TitleLaF_3:Tb Nanoparticles Coated with 5-Aminoisophthalic Acid Sensitizer and Their Applications in Immunolabeling and Imaging of Hela Cells
Zhang YongFang1; Yu YongLi1; Zhang Ning1; Wang Meng2; Xu ShuKun1
2014
Source PublicationCHINESE JOURNAL OF INORGANIC CHEMISTRY
ISSN1001-4861
Volume30Issue:10Pages:2315-2322
Abstract5-aminoisophthalic acid (AIPA) sentisized LaF3:Tb nanoparticles (AIPA-LaF3:Tb) with good water solubility were synthesized by one-step hydrothermal method using Ln(NO3)(3) (Ln=La/Tb), NH4F, AIPA and citrate acid as raw materials. The particles were characterized by XRD, TEM and FTIR. The results show that the as-prepared particles are single-phase LaF3 crystals coated with AIPA in hexagonal system with narrowly distributed particles size of about 8 nm. The luminescence properties of the particles were investigated and the energy transfer between AIPA and Tb3+ was observed with the strongest excitation peak of 348 nm and the strongest emission peak of 547 nm. Compared with those of LaF3:Ce,Tb nanoparticles, the excitation wavelength of AIPA-LaF3:Tb nanoparticles has a red-shift of 94 nm and the emission intensity is increased markedly.The results for lifetime evaluation of AIPA-LaF3:Tb nanoparticles reveal that the luminescence of AIPA-LaF3:Tb nanoparticles originates from the Tb3+ near or at the surfaces of the particles. After preparation, AIPA-LaF3:Tb nanoparticles were coated with amino-SiO2, and then were covalently linked to rabbit anti-CEA polyclone antibodies to form the conjugates. Finally, based on the specific combination of carcinoembryonic antigen (CEA) expressed on the surface of Hela cells with anti-CEA antibodies, AIPA-LaF3:Tb nanoparticles were used in immunolabeling and imaging of Hela cells.
KeywordLANTHANIDE NANOPARTICLES LUMINESCENT PROPERTIES TB NANOPARTICLES CONVERSION PHOSPHORS LaF3:Tb 5-aminoisophthalic acid luminescent nanoparticle cell imaging
Indexed ByCSCD
Language英语
CSCD IDCSCD:5266077
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/143076
Collection中国科学院金属研究所
Affiliation1.东北大学
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang YongFang,Yu YongLi,Zhang Ning,et al. LaF3:Tb Nanoparticles Coated with 5-Aminoisophthalic Acid Sensitizer and Their Applications in Immunolabeling and Imaging of Hela Cells[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2014,30(10):2315-2322.
APA Zhang YongFang,Yu YongLi,Zhang Ning,Wang Meng,&Xu ShuKun.(2014).LaF3:Tb Nanoparticles Coated with 5-Aminoisophthalic Acid Sensitizer and Their Applications in Immunolabeling and Imaging of Hela Cells.CHINESE JOURNAL OF INORGANIC CHEMISTRY,30(10),2315-2322.
MLA Zhang YongFang,et al."LaF3:Tb Nanoparticles Coated with 5-Aminoisophthalic Acid Sensitizer and Their Applications in Immunolabeling and Imaging of Hela Cells".CHINESE JOURNAL OF INORGANIC CHEMISTRY 30.10(2014):2315-2322.
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