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Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases
Alternative TitleLog-normal censored regression model detecting prognostic factors in gastric cancer:A study of 3018 cases
Wang BinBin; Liu CaiGang; Lu Ping; Latengbaolide A; Lu Yang
2011
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume17Issue:23Pages:2867-2872
AbstractAIM: To investigate the efficiency of Cox proportional hazard model in detecting prognostic factors for gastric cancer.
Other AbstractAIM:To investigate the efficiency of Cox proportional hazard model in detecting prognostic factors for gastric cancer.METHODS:We used the log-normal regression model to evaluate prognostic factors in gastric cancer and compared it with the Cox model.Three thousand and eighteen gastric cancer patients who received a gastrectomy between 1980 and 2004 were retrospectively evaluated.Clinic-pathological factors were included in a log-normal model as well as Cox model.The akaike information criterion(AIC)was employed to compare the efficiency of both models.Univariate analysis indicated that age at diagnosis,past history,cancer location,distant metastasis status,surgical curative degree,combined other organ resection,Borrmann type,Lauren’s classification,pT stage,total dissected nodes and pN stage were prognostic factors in both log-normal and Cox models.RESULTS:In the final multivariate model,age at diagnosis,past history,surgical curative degree,Borrmann type,Lauren’s classification,pT stage,and pN stage were significant prognostic factors in both log-normal and Cox models.However,cancer location,distant metastasis status,and histology types were found to be significant prognostic factors in log-normal results alone.According to AIC,the log-normal model performed better than the Cox proportional hazard model(AIC value:2534.72 vs 1693.56).CONCLUSION:It is suggested that the log-normal regression model can be a useful statistical model to evaluate prognostic factors instead of the Cox proportional hazard model.
KeywordSURGERY Gastric cancer Log normal regression model Cox proportional hazard model Prognostic factors
Indexed ByCSCD
Language英语
Funding Project[Gastric Cancer Laboratory] ; [Department of Chinese Medical University, Shenyang, China] ; [Science and Technology Program of Shenyang]
CSCD IDCSCD:4251556
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/143436
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang BinBin,Liu CaiGang,Lu Ping,et al. Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(23):2867-2872.
APA Wang BinBin,Liu CaiGang,Lu Ping,Latengbaolide A,&Lu Yang.(2011).Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases.WORLD JOURNAL OF GASTROENTEROLOGY,17(23),2867-2872.
MLA Wang BinBin,et al."Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases".WORLD JOURNAL OF GASTROENTEROLOGY 17.23(2011):2867-2872.
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