| Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children | |
| Alternative Title | Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children |
| Ma Xiang1; Yao Kaihu1; Xie Guilin2; Zheng Yuejie3; Wang Chuanqing4; Shang Yunxiao5; Wang Huiyun6; Wan Liya7; Liu Lan8; Li Changchong9; Ji Wei10; Xu Xiwei1; Wang Yating11; Xu Peiru12; Yu Sangjie1; Yang Yonghong1 | |
| 2013 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 126Issue:8Pages:1522-1527 |
| Abstract | Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. |
| Other Abstract | Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. Methods A total of 171 S. pneumoniae strains were isolated from 11 medical centers in China from 2006 to 2008. All the isolates were characterized via serotyping and antibiotic susceptibility determination. The erythromycin-resistant isolates were further characterized via ermB and mefA gene detection, multi-locus sequence typing analysis, and pulsed-field gel electrophoresis. Results A total of 164 (95.9%) isolates showed resistance to erythromycin, of which 162 strains with high high-level resistance (MIC ≥ 256 μg/ml). A total of 104 (63.4%) isolates carry the ermB gene alone, whereas 59 (36.0%) harbor both ermB and mefA genes. Of the 59 strains, 54 were of serotypes 19A and 19F and were identified as highly clonal and related to the Taiwan~(19F)-14 clone. Conclusions The erythromycin resistance rate in IPD isolates is significantly high and is predominantly mediated by the ermB gene. Isolates that carry both ermB and mefA genes are predominantly of serotypes 19A and 19F. |
| Keyword | PNEUMOCOCCAL CONJUGATE VACCINE ANTIMICROBIAL RESISTANCE MACROLIDE RESISTANCE PATHOGENS ANSORP ASIAN NETWORK SEROTYPE DISTRIBUTION UNITED-STATES SURVEILLANCE MECHANISMS INFECTIONS Streptococcus pneumonia invasive pneumococcal diseases erythromycin resistance genes |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Beijing Nova Program] ; [Special Fund for High-level Personnel Development in the Beijing Health System] ; [Beijing Guidance Teacher Technology Item of Excellent Doctorship Thesis] |
| CSCD ID | CSCD:4808208 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/143793 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.上海市地震局 2.中国地震局地震数据信息中心 3.Shenzhen Childrens Hosp, Shenzhen 518000, Guangdong, Peoples R China 4.复旦大学 5.中国科学院金属研究所 6.中国科学院南京地理与湖泊研究所 7.Tianjin Childrens Hosp, Tianjin 300000, Peoples R China 8.Chongqing Med University, Chongqing Childrens Hosp, Chongqing 401000, Peoples R China 9.Wenzhou Med Coll, Yuying Childrens Hosp, Wenzhou 325500, Zhejiang, Peoples R China 10.苏州大学 11.Anhui Med University Affiliated Hosp, Hefei 230100, Anhui, Peoples R China 12.Xinjiang Med University, Affiliated Hosp 1, Urumqi 830000, Xijiang, Peoples R China |
| Recommended Citation GB/T 7714 | Ma Xiang,Yao Kaihu,Xie Guilin,et al. Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children[J]. CHINESE MEDICAL JOURNAL,2013,126(8):1522-1527. |
| APA | Ma Xiang.,Yao Kaihu.,Xie Guilin.,Zheng Yuejie.,Wang Chuanqing.,...&Yang Yonghong.(2013).Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children.CHINESE MEDICAL JOURNAL,126(8),1522-1527. |
| MLA | Ma Xiang,et al."Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children".CHINESE MEDICAL JOURNAL 126.8(2013):1522-1527. |
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