Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children

IMR OpenIR

	Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children
其他题名	Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children
	Ma Xiang 1; Yao Kaihu 1; Xie Guilin 2; Zheng Yuejie 3; Wang Chuanqing 4; Shang Yunxiao 5; Wang Huiyun 6; Wan Liya 7; Liu Lan 8; Li Changchong 9; Ji Wei 10; Xu Xiwei 1; Wang Yating 11; Xu Peiru 12; Yu Sangjie 1; Yang Yonghong 1
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	126 期号:8 页码:1522-1527
摘要	Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children.
其他摘要	Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. Methods A total of 171 S. pneumoniae strains were isolated from 11 medical centers in China from 2006 to 2008. All the isolates were characterized via serotyping and antibiotic susceptibility determination. The erythromycin-resistant isolates were further characterized via ermB and mefA gene detection, multi-locus sequence typing analysis, and pulsed-field gel electrophoresis. Results A total of 164 (95.9%) isolates showed resistance to erythromycin, of which 162 strains with high high-level resistance (MIC ≥ 256 μg/ml). A total of 104 (63.4%) isolates carry the ermB gene alone, whereas 59 (36.0%) harbor both ermB and mefA genes. Of the 59 strains, 54 were of serotypes 19A and 19F and were identified as highly clonal and related to the Taiwan~(19F)-14 clone. Conclusions The erythromycin resistance rate in IPD isolates is significantly high and is predominantly mediated by the ermB gene. Isolates that carry both ermB and mefA genes are predominantly of serotypes 19A and 19F.
关键词	PNEUMOCOCCAL CONJUGATE VACCINE ANTIMICROBIAL RESISTANCE MACROLIDE RESISTANCE PATHOGENS ANSORP ASIAN NETWORK SEROTYPE DISTRIBUTION UNITED-STATES SURVEILLANCE MECHANISMS INFECTIONS Streptococcus pneumonia invasive pneumococcal diseases erythromycin resistance genes
收录类别	CSCD
语种	英语
资助项目	[Beijing Nova Program] ; [Special Fund for High-level Personnel Development in the Beijing Health System] ; [Beijing Guidance Teacher Technology Item of Excellent Doctorship Thesis]
CSCD记录号	CSCD:4808208
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/143793
专题	中国科学院金属研究所
作者单位	1.上海市地震局 2.中国地震局地震数据信息中心 3.Shenzhen Childrens Hosp, Shenzhen 518000, Guangdong, Peoples R China 4.复旦大学 5.中国科学院金属研究所 6.中国科学院南京地理与湖泊研究所 7.Tianjin Childrens Hosp, Tianjin 300000, Peoples R China 8.Chongqing Med University, Chongqing Childrens Hosp, Chongqing 401000, Peoples R China 9.Wenzhou Med Coll, Yuying Childrens Hosp, Wenzhou 325500, Zhejiang, Peoples R China 10.苏州大学 11.Anhui Med University Affiliated Hosp, Hefei 230100, Anhui, Peoples R China 12.Xinjiang Med University, Affiliated Hosp 1, Urumqi 830000, Xijiang, Peoples R China
推荐引用方式 GB/T 7714	Ma Xiang,Yao Kaihu,Xie Guilin,et al. Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children[J]. CHINESE MEDICAL JOURNAL,2013,126(8):1522-1527.
APA	Ma Xiang.,Yao Kaihu.,Xie Guilin.,Zheng Yuejie.,Wang Chuanqing.,...&Yang Yonghong.(2013).Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children.CHINESE MEDICAL JOURNAL,126(8),1522-1527.
MLA	Ma Xiang,et al."Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children".CHINESE MEDICAL JOURNAL 126.8(2013):1522-1527.