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Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
Alternative TitleSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
Sun ChiYu1; Li YangSheng1; Shi AiLong1; Li YaFei1; Cao RuiFang1; Ding HuaiWei1; Yin QingQing1; Zhang LiJuan1; Zheng HuaChuan2; Song HongRui1
2015
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume26Issue:10Pages:1307-1310
AbstractA series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Other AbstractA series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibitedmoderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.
KeywordHEDGEHOG SIGNALING PATHWAY BASAL-CELL CARCINOMA INHIBITORS DISCOVERY DESIGN ANTAGONISTS IDENTIFICATION VISMODEGIB CANCER POTENT Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling
Indexed ByCSCD
Language英语
Funding Project[Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University] ; [Innovation and entrepreneurship training program for college students in Liaoning Province]
CSCD IDCSCD:5542180
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144039
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Liaoning Med University, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
Recommended Citation
GB/T 7714
Sun ChiYu,Li YangSheng,Shi AiLong,et al. Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives[J]. CHINESE CHEMICAL LETTERS,2015,26(10):1307-1310.
APA Sun ChiYu.,Li YangSheng.,Shi AiLong.,Li YaFei.,Cao RuiFang.,...&Song HongRui.(2015).Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives.CHINESE CHEMICAL LETTERS,26(10),1307-1310.
MLA Sun ChiYu,et al."Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives".CHINESE CHEMICAL LETTERS 26.10(2015):1307-1310.
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