| Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives | |
| Alternative Title | Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives |
| Sun ChiYu1; Li YangSheng1; Shi AiLong1; Li YaFei1; Cao RuiFang1; Ding HuaiWei1; Yin QingQing1; Zhang LiJuan1; Zheng HuaChuan2; Song HongRui1 | |
| 2015 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 26Issue:10Pages:1307-1310 |
| Abstract | A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Other Abstract | A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibitedmoderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. |
| Keyword | HEDGEHOG SIGNALING PATHWAY BASAL-CELL CARCINOMA INHIBITORS DISCOVERY DESIGN ANTAGONISTS IDENTIFICATION VISMODEGIB CANCER POTENT Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University] ; [Innovation and entrepreneurship training program for college students in Liaoning Province] |
| CSCD ID | CSCD:5542180 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/144039 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Liaoning Med University, Affiliated Hosp 1, Jinzhou 121001, Peoples R China |
| Recommended Citation GB/T 7714 | Sun ChiYu,Li YangSheng,Shi AiLong,et al. Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives[J]. CHINESE CHEMICAL LETTERS,2015,26(10):1307-1310. |
| APA | Sun ChiYu.,Li YangSheng.,Shi AiLong.,Li YaFei.,Cao RuiFang.,...&Song HongRui.(2015).Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives.CHINESE CHEMICAL LETTERS,26(10),1307-1310. |
| MLA | Sun ChiYu,et al."Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives".CHINESE CHEMICAL LETTERS 26.10(2015):1307-1310. |
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