Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives

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	Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
其他题名	Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
	Sun ChiYu 1; Li YangSheng 1; Shi AiLong 1; Li YaFei 1; Cao RuiFang 1; Ding HuaiWei 1; Yin QingQing 1; Zhang LiJuan 1; Zheng HuaChuan 2; Song HongRui 1
	2015
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	26 期号:10 页码:1307-1310
摘要	A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
其他摘要	A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibitedmoderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.
关键词	HEDGEHOG SIGNALING PATHWAY BASAL-CELL CARCINOMA INHIBITORS DISCOVERY DESIGN ANTAGONISTS IDENTIFICATION VISMODEGIB CANCER POTENT Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling
收录类别	CSCD
语种	英语
资助项目	[Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University] ; [Innovation and entrepreneurship training program for college students in Liaoning Province]
CSCD记录号	CSCD:5542180
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144039
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Liaoning Med University, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
推荐引用方式 GB/T 7714	Sun ChiYu,Li YangSheng,Shi AiLong,et al. Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives[J]. CHINESE CHEMICAL LETTERS,2015,26(10):1307-1310.
APA	Sun ChiYu.,Li YangSheng.,Shi AiLong.,Li YaFei.,Cao RuiFang.,...&Song HongRui.(2015).Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives.CHINESE CHEMICAL LETTERS,26(10),1307-1310.
MLA	Sun ChiYu,et al."Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives".CHINESE CHEMICAL LETTERS 26.10(2015):1307-1310.