| Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines | |
| Alternative Title | Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines |
| Zhai Xin; Jiang Nan; Zhang Ke Liang; Bao Feng; Gong Ping | |
| 2009 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 20Issue:10Pages:1179-1182 |
| Abstract | In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT-1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed. (C) 2009 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT- 1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed. |
| Keyword | SAR Triazolo1,5-apyrimidines Synthesis Antiproliferative activity |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3771711 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/144123 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhai Xin,Jiang Nan,Zhang Ke Liang,et al. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines[J]. CHINESE CHEMICAL LETTERS,2009,20(10):1179-1182. |
| APA | Zhai Xin,Jiang Nan,Zhang Ke Liang,Bao Feng,&Gong Ping.(2009).Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines.CHINESE CHEMICAL LETTERS,20(10),1179-1182. |
| MLA | Zhai Xin,et al."Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines".CHINESE CHEMICAL LETTERS 20.10(2009):1179-1182. |
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