Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines

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	Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines
其他题名	Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines
	Zhai Xin; Jiang Nan; Zhang Ke Liang; Bao Feng; Gong Ping
	2009
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	20 期号:10 页码:1179-1182
摘要	In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT-1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed. (C) 2009 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT- 1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed.
关键词	SAR Triazolo1,5-apyrimidines Synthesis Antiproliferative activity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3771711
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144123
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhai Xin,Jiang Nan,Zhang Ke Liang,et al. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines[J]. CHINESE CHEMICAL LETTERS,2009,20(10):1179-1182.
APA	Zhai Xin,Jiang Nan,Zhang Ke Liang,Bao Feng,&Gong Ping.(2009).Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines.CHINESE CHEMICAL LETTERS,20(10),1179-1182.
MLA	Zhai Xin,et al."Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines".CHINESE CHEMICAL LETTERS 20.10(2009):1179-1182.