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Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines
Alternative TitleDesign, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines
Zhai Xin; Jiang Nan; Zhang Ke Liang; Bao Feng; Gong Ping
2009
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume20Issue:10Pages:1179-1182
AbstractIn our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT-1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed. (C) 2009 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractIn our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo1,5-apyrimidines (6-16). Their antiproliferative activity against Bel-7402, HT- 1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds (9-11 and 16) displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed.
KeywordSAR Triazolo1,5-apyrimidines Synthesis Antiproliferative activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3771711
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144126
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhai Xin,Jiang Nan,Zhang Ke Liang,et al. Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines[J]. CHINESE CHEMICAL LETTERS,2009,20(10):1179-1182.
APA Zhai Xin,Jiang Nan,Zhang Ke Liang,Bao Feng,&Gong Ping.(2009).Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines.CHINESE CHEMICAL LETTERS,20(10),1179-1182.
MLA Zhai Xin,et al."Design, synthesis and antiproliferative activity of novel 2,7-disubstituted triazolo1,5-apyrimidines".CHINESE CHEMICAL LETTERS 20.10(2009):1179-1182.
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