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N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats
Alternative TitleN-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats
Zhu Qiwen; Hou Weijian; Zhao Jianwen; Yang Yu; Zhang Qi; Guo Li; Shang Lihong; Cao Yinglin; Wu Chunfu
2010
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume5Issue:23Pages:1787-1794
AbstractLead exposure induces decreased hippocampal N-methyl-D-aspartic acid (NMDA) receptor gene and protein expressions, which influences the molecular mechanisms of learning and memory. However, lead poisoning-induced differences in NMDA subunit expression, and the correlation of lead poisoning with learning and memory, remain poorly understood. The present study measured differences in expression of NMDA receptor subunits NR1, NR2A, and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure. Results demonstrated decreased NR1, NR2A, and NR2B subunit expressions in some memory-related brain areas. The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant, although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure. There was no difference in NR1 expression following exposure to <4.8 mmol/L lead, although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus. Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory. Therefore, lead toxicity was dependent on NMDA receptor subunit composition, and NR1, NR2A, and NR2B expressions were associated with time and concentration of lead exposure.
Other AbstractLead exposure induces decreased hippocampal N-methyl-D-aspartic acid (NMDA) receptor gene and protein expressions, which influences the molecular mechanisms of learning and memory. However, lead poisoning-induced differences in NMDA subunit expression, and the correlation of lead poisoning with learning and memory, remain poorly understood. The present study measured differences in expression of NMDA receptor subunits NR1, NR2A, and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure. Results demonstrated decreased NR1, NR2A, and NR2B subunit expressions in some memory-related brain areas. The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant, although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure. There was no difference in NR1 expression following exposure to < 4.8 mmol/L lead, although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus. Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory. Therefore, lead toxicity was dependent on NMDA receptor subunit composition, and NR1, NR2A, and NR2B expressions were associated with time and concentration of lead exposure
KeywordSURFACE EXPRESSION MESSENGER-RNA HIPPOCAMPAL NEUROTOXICITY DISEASE SYSTEM INJURY WATER lead exposure N-methyl-D-aspartate receptor memory-related brain areas neural regeneration rats
Indexed ByCSCD
Language英语
Funding Project[Science and Technology Bureau of Liaoning Province]
CSCD IDCSCD:4100499
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144132
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhu Qiwen,Hou Weijian,Zhao Jianwen,et al. N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats[J]. NEURAL REGENERATION RESEARCH,2010,5(23):1787-1794.
APA Zhu Qiwen.,Hou Weijian.,Zhao Jianwen.,Yang Yu.,Zhang Qi.,...&Wu Chunfu.(2010).N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats.NEURAL REGENERATION RESEARCH,5(23),1787-1794.
MLA Zhu Qiwen,et al."N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats".NEURAL REGENERATION RESEARCH 5.23(2010):1787-1794.
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