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Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
Alternative TitleInitiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
Yu Hui1; Xie LiFang2; Chen Kang1; Yang GangYi3; Xing XiaoYan4; Zhao JiaJun5; Hong TianPei6; Shan ZhongYan7; Li HongMei8; Chen Bing9; Tang XuLei10; Qi Ling11; Yang Jing12; Fang Yuan13; Li Ting1; Wang ShuangShuang1; Liang Xue1; Yin YaQi1; Mu YiMing1
2016
Source PublicationChinese Medical Journal
ISSN0366-6999
Volume129Issue:7Pages:778-784
AbstractBackground: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio OR 446.99, 95% confidence interval CI 42.37–4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47–38.03), dyslipidemia (OR 2.65, CI 1.54–4.56), diastolic blood pressure (OR 1.02, CI 1.00–1.04), and body mass index (OR 0.95, CI 0.92–0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
Other AbstractBackground: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio OR 446.99, 95% confidence interval CI 42.37–4714.87), family history of diabetes mellitus ( OR 23.46, CI 14.47–38.03), dyslipidemia ( OR 2.65, CI 1.54–4.56), diastolic blood pressure ( OR 1.02, CI 1.00–1.04), and body mass index ( OR 0.95, CI 0.92–0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
KeywordObesity Medicine R Risk Factor Type 2 Diabetes Mellitus Young
Indexed ByCSCD
Language英语
Funding Project[National Science and Technology Major Project]
CSCD IDCSCD:5674625
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144172
Collection中国科学院金属研究所
Affiliation1.中国人民解放军总医院
2.Chinese Peoples Liberat Army 155 Hosp, Department Endocrinol, Kaifeng 475003, Henan, Peoples R China Department Endocrinol
3.Chongqing Med University, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China
4.China Japan Friendship Hosp, Department Endocrinol, Beijing 100029, Peoples R China
5.山东大学
6.北京大学
7.中国科学院金属研究所
8.China Meitan Gen Hosp, Department Endocrinol, Beijing 100028, Peoples R China
9.Third Mil Med University, Southwest Hosp, Dept Endocrinol & Metab, Chongqing 400038, Peoples R China
10.兰州大学
11.Beijing Yanhua Hosp, Department Endocrinol, Beijing 102500, Peoples R China
12.Shanxi Med University, Hosp 1, Dept Endocrinol, Taiyuan 030001, Shanxi, Peoples R China
13.Capital Med University, Beijing Luhe Hosp, Dept Endocrinol, Beijing 101100, Peoples R China
Recommended Citation
GB/T 7714
Yu Hui,Xie LiFang,Chen Kang,et al. Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients[J]. Chinese Medical Journal,2016,129(7):778-784.
APA Yu Hui.,Xie LiFang.,Chen Kang.,Yang GangYi.,Xing XiaoYan.,...&Mu YiMing.(2016).Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients.Chinese Medical Journal,129(7),778-784.
MLA Yu Hui,et al."Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients".Chinese Medical Journal 129.7(2016):778-784.
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